{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T18:27:43Z","timestamp":1750184863555,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background:<\/i> Sinus node dysfunction (SND) is a heterogeneous disorder of unknown etiology characterized by a variety of supraventricular arrhythmias with symptoms of syncope, palpitations, and dizziness. The mechanism underlying the abnormal rhythm is incompletely understood. <i>Objective:<\/i> Because vagal stimulation and acetylcholine (ACh) affect the function of pacemaker cells, we hypothesized that genetic variation in the genes encoding the ACh-activated K<sup>+<\/sup> channels, the KACh channels, could be involved in the pathogenesis of SND. <i>Methods and Results:<\/i> We screened 184 patients listed in the pacemaker registry of the Copenhagen University Hospital aged <60 years at pacemaker implantation for SND in the period 1982\u20132005. Forty-three patients fulfilled the following inclusion criteria: documented sinus arrest, asystole, or extreme sinus bradycardia. The coding sequences of <i>KCNJ3<\/i> and <i>KCNJ5,<\/i> encoding the main subunits of the KACh channels, were re-sequenced. We identified several known single nucleotide polymorphisms in <i>KCNJ3<\/i> and <i>KCNJ5<\/i>, but no mutations in either of the genes. <i>Conclusions:<\/i> Genetic variation in <i>KCNJ3<\/i> and <i>KCNJ5<\/i> encoding the subunits of the KACh channels is apparently not involved in the pathogenesis of SND.<\/jats:p>","DOI":"10.1159\/000279319","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T11:49:58Z","timestamp":1264765798000},"page":"176-181","source":"Crossref","is-referenced-by-count":9,"title":["Genetic Variation in the Inwardly Rectifying K<sup>+<\/sup> Channel Subunits <i>KCNJ3<\/i> (<i>GIRK1<\/i>) and <i>KCNJ5<\/i> (<i>GIRK4<\/i>) in Patients with Sinus Node Dysfunction"],"prefix":"10.1159","volume":"115","author":[{"given":"Haya N.","family":"Holmegard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane","family":"Theilade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Benn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Duno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stig","family":"Haunso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper H.","family":"Svendsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.40.11.1314"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tcm.2003.09.006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.274.18.12517"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M209599200"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2801%2901304-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2F374135a0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.273.9.5271"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1006%2Fgeno.1996.4495"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M104851200"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0896-6273%2895%2990101-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.1995.2072"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2895%2990122-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.genom.7.080505.115630"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cyto.2006.07.008"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pgen.0010083"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pone.0003575"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.a.32704"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093%2Feuropace%2Feun289"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1540-8167.2007.01087.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097%2FFJC.0b013e31816c4325"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2007.10.106"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/279319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/279319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:08:51Z","timestamp":1745442531000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000279319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,4,1]]},"published-print":{"date-parts":[[2010,4,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000279319","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"type":"print","value":"0008-6312"},{"type":"electronic","value":"1421-9751"}],"subject":[],"published":{"date-parts":[[2010]]}}}