{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:42:34Z","timestamp":1745469754776,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Studies on the natural history of rare, chronic diseases like spinocerebellar ataxia 3 (SCA3) are hard to be done, since patients enter the study with variable disease durations and are followed up at irregular intervals. &lt;i&gt;Aims:&lt;\/i&gt; Our purpose was to use all the available data to describe the progression of gait ataxia in a long-term cohort of patients with SCA3 through a markovian method. &lt;i&gt;Materials and Methods:&lt;\/i&gt; SCA3 patients were recruited between 1998 and 2005 and were invited to annual neurological follow-ups until 2007. Gait ataxia was described through a mean score graph and a mean trajectory graph. &lt;i&gt;Results:&lt;\/i&gt; We followed up 105 patients; at baseline, the mean age and disease duration were, 40.5 (SD = 12.6) and 7.7 (SD = 5.8) years, respectively. The mean time to reach stages 1, 2, 3 and 4 of gait ataxia were 3, 5.4, 10.8 and 19.4 years of disease duration. The mean score graph was unsmooth, showing several unlikely ups and downs. The mean trajectory graph produced a continuous curve. &lt;i&gt;Conclusion:&lt;\/i&gt; The markovian method described the natural history of gait ataxia without any a posteriori adjustment of data and allowed statistical comparisons between subgroups. This method will be useful in future clinical trials in this and in other chronic degenerative diseases.<\/jats:p>","DOI":"10.1159\/000279333","type":"journal-article","created":{"date-parts":[[2010,2,2]],"date-time":"2010-02-02T08:42:27Z","timestamp":1265100147000},"page":"163-170","source":"Crossref","is-referenced-by-count":4,"title":["A Prospective Study of SCA3 Gait Ataxia Described through a Markovian Method"],"prefix":"10.1159","volume":"34","author":[{"given":"Suzi","family":"Camey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Bannach","family":"Jardim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kieling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas Alex Morales","family":"Saute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Vigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,2,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0258%2819981030%2917%3A20%3C2395%3A%3AAID-SIM932%3E3.0.CO%3B2-Q"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000110379"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1214%2Faoms%2F1177707039"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0793-300"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fng1194-221"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-1331.2008.02078.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F121.4.589"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F4.5.807"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410420615"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2804%2900737-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-0004.2007.00910.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000325057.33666.72"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.22627"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/279333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/279333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:09:04Z","timestamp":1745442544000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000279333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000279333","archive":["Portico"],"relation":{},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"type":"print","value":"0251-5350"},{"type":"electronic","value":"1423-0208"}],"subject":[],"published":{"date-parts":[[2010]]}}}