{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:00:15Z","timestamp":1777870815266,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"abstract":"<jats:p>Chez les malades atteints de tuberculose uro-g\u00e9nitale et d\u2019une insuffisance des gonades cliniquement d\u00e9finie, nous avons \u00e9tabli que chez les hommes, le m\u00e9tabolisme des hormones androg\u00e8nes se d\u00e9place quantitativement vers la formation de l\u2019aethiocholanolone. L\u2019\u00e9limination de l\u2019androst\u00e9rone et celle de la d\u00e9hidro\u00e9piandrost\u00e9rone est abaiss\u00e9e. Le m\u00e9tabolisme de la testosterone exog\u00e8ne subit la m\u00eame deviation vers la formation pr\u00e9ferentielle de l\u2019aethiocholanolone. L\u2019insucc\u00e8s d\u2019un traitement par la testosterone chez ces malades devient expliquable par cette transformation en metabolites biologiquement inactifs. L\u2019\u00e9limination des oestrog\u00e8nes qui d\u00e9passe largement les valeurs normales est surtout sous l\u2019influence de l\u2019action de l\u2019AGTH. Chez les femmes atteintes de tuberculose uro-g\u00e9nitale l\u2019insuffisance des gonades est caract\u00e9ris\u00e9e par une elimination des oestrog\u00e8nes dont les variations sont considerables et par une elimination augment\u00e9e de pregnandiol pendant toute la dur\u00e9e du cycle menstruel. L\u2019\u00e9limination abaiss\u00e9e de 17-OH-CS que nous avons constate chez nos malades et la r\u00e9ponse diminu\u00e9e \u00e0 l\u2019action de l\u2019ACTH nous ont permis de confirmer les signes cliniques de l\u2019insuffisance surr\u00e9nale que ces malades pr\u00e9sentent souvent.<\/jats:p>","DOI":"10.1159\/000279425","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T06:49:58Z","timestamp":1264747798000},"page":"289-306","source":"Crossref","is-referenced-by-count":0,"title":["Les modifications hormonales chez les tuberculeux uro-g\u00e9nitaux"],"prefix":"10.1159","author":[{"given":"T.","family":"Burghele","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Apostol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Albescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,26]]},"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000279425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:43:47Z","timestamp":1777567427000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000279425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000279425","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,26]]}}}