{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:00:34Z","timestamp":1777870834622,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"abstract":"<jats:p>There is no absolute clinical picture distinguishing renovascular hypertension from essential hypertension. The most useful clues have been the onset of hypertension in persons under thirty or over fifty, an accelerated course or a history of unexplained flank or abdominal pain. Upper abdominal bruits exist in 50% or more of cases of renal artery stenosis with a higher incidence being observed in patients with fibromuscular dysplasias than with atherosclerotic stenosis. The radioactive renogram is a useful screening device, positive in approximately 86% of patients but subject to many false positive interpretations. When all parameters of the intravenous urogram are considered, 90% of patients with proven renal artery stenosis show a positive correlation. The divided kidney function test is useful in providing functional information of the kidneys, but lacks definitive exactitude. The renal arteriogram is a sine qua non to provide anatomical definition of a stenosing lesion but functional significance of a stenosis can only be surmised by the degree of luminal compromise. Renal biopsy has been useful in demonstrating tubular atrophy, small vessel disease and changes in the juxta glomerular apparatus. Severe ipsilateral tubular atrophy suggests the need for nephrectomy rather than revascularization and in this regard appears to have prognostic value. Measurement of pressure gradient and renal blood flow are highly desirable in determining the functional significance of an anatomical stenosing lesion. The combination of pressure gradient and renal blood flow provides the best information since either test individually may give misleading information.<\/jats:p>","DOI":"10.1159\/000279594","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T06:49:58Z","timestamp":1264747798000},"page":"1-11","source":"Crossref","is-referenced-by-count":3,"title":["Further Experiences in the Diagnosis and Treatment of Renovascular Hypertension"],"prefix":"10.1159","author":[{"given":"Joseph J.","family":"Kaufman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei N.","family":"Lupu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morton H.","family":"Maxwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,26]]},"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000279594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:45:00Z","timestamp":1777567500000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000279594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000279594","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,26]]}}}