{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:59:00Z","timestamp":1770739140080,"version":"3.49.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background:<\/i> Raised upper airway resistance may be involved in apnea of prematurity (AOP). <i>Objectives:<\/i> To determine the effects of an oral versus a nasal gastric tube on episodes of hypoxemia and bradycardia in infants with AOP. <i>Methods:<\/i> In a randomized controlled cross-over trial, 32 infants (median gestational age 29 (range 24\u201331) weeks, postmenstrual age at study 32 (range 30\u201335) weeks) with the need for tube feeding and symptoms of AOP underwent a 24-hour recording of breathing movements, nasal airflow, heart rate, pulse oximeter saturation and pulse waveforms. A 5-Fr feeding tube was placed orally or nasally for 12 h each, the position selected first was randomly assigned. When the feeding tube was placed nasally, always the smaller nostril was selected. Each infant acted as his\/her own control. Recordings were analyzed for the summed rate of bradycardia and desaturation (heart rate <2\/3 of baseline, saturation \u226480%). <i>Results:<\/i> The route of placing the feeding tube had no significant effect on the summed rate of bradycardia and desaturation (nasal route: median 1.6, CI 0.8\u20131.9; oral route: median 1.0, CI 0.9\u20131.6, p = 0.25). <i>Conclusion:<\/i> We could not confirm an advantage of placing a feeding tube orally in these infants with AOP, as the oral route did not improve their symptoms of AOP. Possible explanations include: (i) the increase in nasal airway resistance by the 5-Fr nasogastric tube, inserted into the smaller nostril, is too small to have any effect on AOP; (ii) any benefit of the oral route is neutralized by the negative effects of an enhanced vagal stimulation, or (iii) study duration was too short to detect a difference in AOP.<\/jats:p>","DOI":"10.1159\/000279617","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T08:07:18Z","timestamp":1268726838000},"page":"143-149","source":"Crossref","is-referenced-by-count":20,"title":["Oral versus Nasal Route for Placing Feeding Tubes: No Effect on Hypoxemia and Bradycardia in Infants with Apnea of Prematurity"],"prefix":"10.1159","volume":"98","author":[{"given":"Bettina","family":"Bohnhorst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Cech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinna","family":"Peter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Doerdelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,3,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000097446"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.55.1.17"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.51.8.602"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.66.5.569"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.61.3.227"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199308000-00007"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1990.tb11546.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2869.2006.00511.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fppul.1950080408"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1552-6909.1995.tb02483.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-3782%2894%2901605-O"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2881%2991795-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0278-2391%2892%2990199-A"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fppul.20832"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/279617","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/279617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:12:21Z","timestamp":1745442741000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000279617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,8,1]]},"published-print":{"date-parts":[[2010,8,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000279617","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}