{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:00:33Z","timestamp":1777870833102,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"abstract":"<jats:p>Bei 23 Patienten mit benignen Prostata-Adenomen und 13 Prostatakarzinomtr\u00e4gern wurden durch perineale Prostatapunktion gewonnene Gewebszylinder fermenthistochemisch untersucht, wobei neben der sauren Gewebsphosphatase folgende, innerhalb verschiedener Stoffwechselzyklen wirkende Fermente ber\u00fccksichtigt wurden: Succino-Dehydrogenase, Isozitrat-Dehydrogenase (NADP), \u03b2-Hydroxybutyrat-Dehydrogenase, Glukose-6-Phosphat-Dehydrogenase, Glutamat-Dehydrogenase und Laktat-Dehydro-genase. Mit Ausnahme der Glukose-6-Phosphat-Dehydrogenase, deren fast vollst\u00e4ndiges Fehlen eine Energiegewinnung \u00fcber den Pentosephosphat-Zyklus in der Prostata aus-schliesst, lassen sich s\u00e4mtliche anderen untersuchten oxydativen Enzyme in unter-schiedlicher Aktivit\u00e4tsh\u00f6he vorwiegend in den Epithelien der Dr\u00fcsenacini nachweisen, wobei bei Adenofibromyomatose zwischen normalen und proliferierten Dr\u00fcsenepithelien keine signifikanten Aktivit\u00e4tsunterschiede bestehen. In Abh\u00e4ngigkeit vom Differen-zierungsgrad zeigten die untersuchten Karzinome difl\u2019erente Reaktionsausf\u00e4lle. Mit Ausnahme der Glukose-6-Phosphat-Dehydrogenase zeichnen sich besonders die hochdif\u00eeerenzierten Adenokarzinome durch hohe Aktivit\u00e4ten oxydativer Enzyme sowie der sauren Phosphatase in den Tumorzellen aus bei geringem bis negativem Reaktions-ausfall im Stroma. Beim Carcinoma solidum simplex sive scirrhosum lassen sich auf Grund der geringen Tumorzelldichte geringere Aktivit\u00e4ten oxydativer Enzyme nachweisen als beim Carcinoma solidum medullare. Eine Ausnahme davon bildete die saure Phosphatase, die bei alien Karzinomarten der Prostata stark ausgepr\u00e4gt war.<\/jats:p>","DOI":"10.1159\/000279665","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T06:49:58Z","timestamp":1264747798000},"page":"86-103","source":"Crossref","is-referenced-by-count":8,"title":["Fermenthistochemische Untersuchungen zur Differenzierung benigner und maligner Wachstumsprozesse in der menschlichen Prostata"],"prefix":"10.1159","author":[{"given":"A.","family":"Feustel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sgh\u00f6nfelder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Wohlrab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,26]]},"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000279665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:45:28Z","timestamp":1777567528000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000279665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000279665","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,26]]}}}