{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:01:50Z","timestamp":1777870910170,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T00:00:00Z","timestamp":1264723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T00:00:00Z","timestamp":1264723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"abstract":"<jats:p>To study the role of renal prostaglandins (PGs) in renovascular hypertension, PGE&lt;sub&gt;2&lt;\/sub&gt; and PGF&lt;sub&gt;2&lt;\/sub&gt;&lt;sub&gt;\u03b1&lt;\/sub&gt; concentrations in both inner and outer medullae of the kidney were measured by radioimmunoassay in rabbits with hypertension produced by left renal artery constriction. In the acute phase, a week after the surgery, PGE&lt;sub&gt;2&lt;\/sub&gt; in the inner and outer medullae and PGF&lt;sub&gt;2\u03b1&lt;\/sub&gt; in the inner medulla were significantly increased in both the constricted and opposite kidneys (p &lt; 0.01). In chronic phase, 5 weeks after surgery, PGs returned to normal concentrations with the exceptions of PGE&lt;sub&gt;2&lt;\/sub&gt; in the outer medulla and PGF&lt;sub&gt;2\u03b1&lt;\/sub&gt; in the inner medulla of the constricted kidney. These results suggest that increased renal PGs may not be the cause of hypertension but a defensive reaction to renal ischemia, hypertension and sodium load.<\/jats:p>","DOI":"10.1159\/000280407","type":"journal-article","created":{"date-parts":[[2010,2,2]],"date-time":"2010-02-02T03:42:27Z","timestamp":1265082147000},"page":"158-165","source":"Crossref","is-referenced-by-count":1,"title":["Intrarenal Prostaglandins E\n                    <sub>2<\/sub>\n                    and F\n                    <sub>2<\/sub>\n                    <sub>\u03b1<\/sub>\n                    in Experimental Renovascular Hypertension"],"prefix":"10.1159","author":[{"given":"Hidehisa","family":"Soejima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuma","family":"Tsuruta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Ikegami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,1,29]]},"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000280407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:51:16Z","timestamp":1777567876000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000280407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000280407","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,29]]}}}