{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:30:20Z","timestamp":1789421420845,"version":"build-2803163510"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Philadelphia-negative myeloproliferative disorders (Ph-MPD) are common causes of unusual splanchnic or cerebral vein thrombosis, which is treated with unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH). Heparin-induced thrombocytopenia (HIT) is a dangerous potential complication of this therapy, but it has rarely been reported in Ph-MPD. &lt;i&gt;Patients and Methods:&lt;\/i&gt; We retrospectively reviewed clinical records of 29 patients with Ph-MPD who have been treated with UFH or LMWH for unusual splanchnic or cerebral vein thrombosis (3 cerebral sinus, 6 portal and 20 hepatic vein). The goal of the study was to determine the occurrence of new thrombotic events during heparin therapy secondary to HIT (HITT). &lt;i&gt;Results:&lt;\/i&gt; During heparin therapy, 5 out of the 29 patients (17%) developed a new thrombotic episode (pulmonary embolism) with a high clinical probability of HIT based on the 4 T\u2019s score even though not all the patients developed \u2018true\u2019 thrombocytopenia. A diagnosis of HIT was established in 2 patients (6.8%) through the presence of heparin-related antibodies. &lt;i&gt;Conclusions:&lt;\/i&gt; Ph-MPD patients on heparin warrant careful monitoring and HIT has to be suspected whenever platelet counts drop or a new thrombosis is detectable.<\/jats:p>","DOI":"10.1159\/000280466","type":"journal-article","created":{"date-parts":[[2010,2,4]],"date-time":"2010-02-04T15:32:04Z","timestamp":1265297524000},"page":"140-145","source":"Crossref","is-referenced-by-count":38,"title":["Heparin-Induced Thrombocytopenia in Patients with Philadelphia-Negative Myeloproliferative Disorders and Unusual Splanchnic or Cerebral Vein Thrombosis"],"prefix":"10.1159","volume":"123","author":[{"given":"Maria L.","family":"Randi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Tezza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Scapin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Duner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Scarparo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Scandellari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Fabris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2004.05277.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182%2Fasheducation-2007.1.363"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.510310307"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2006-939432"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2003.04334.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.163.20.2518"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fajh.21128"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2002-04-1199"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-04-014746"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1538-7836.2006.01787.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.130.3.681"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.130.3.631"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2005-03-0912"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9343%2896%2900258-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2005.05381.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1053%2Fjhep.2003.50415"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fajh.20009"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/280466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/280466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:37:39Z","timestamp":1745440659000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000280466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000280466","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}