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CD8 T cells are a double-edged sword in the response to infection with the hepatitis virus. On one hand, rapid activation of CD8 T cells is critically important for the elimination of the virus. On the other hand, in persistent viral infection, the activation of CD8 T cells substantially contributes to liver injury. The clinical course of hepatitis, thus, critically depends on mechanisms regulating the activity of CD8 T cells. In observations in human hepatitis and in mice infected with the lymphocytic choriomeningitis virus, the clinical course of hepatitis is modified by several immunological factors including neutralizing antibodies: RIG-I, TLRs, MyD88, interferon type I, TNF-\u03b1, MHC I, Tap, TCR, CD8, IL-2, IL-7, PD-1, IFN-I, IL-10, IFN-\u03b3, perforins, serotonin and iNOS (table 1) . Additional experimental effort is needed to understand the concerted interplay of those molecules in viral hepatitis of man and mice.<\/jats:p>","DOI":"10.1159\/000282061","type":"journal-article","created":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T13:03:27Z","timestamp":1273583007000},"page":"25-30","source":"Crossref","is-referenced-by-count":3,"title":["Host Mechanisms in Viral Hepatitis"],"prefix":"10.1159","volume":"28","author":[{"given":"Karl 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