{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:05:12Z","timestamp":1777871112815,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T00:00:00Z","timestamp":1265155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T00:00:00Z","timestamp":1265155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"abstract":"<jats:p>The influence of serotonin (5-hydroxytryptamine, 5-HT) on human ureteral smooth muscle was explored in a series of in vitro experiments. 5-HT evoked a dose-dependent contraction of the ureter. The effect of 5-HT was unaltered by blockade of 5HT&lt;sub&gt;3&lt;\/sub&gt; and 5HT&lt;sub&gt;4&lt;\/sub&gt; receptors and muscarinic cholinergic receptors. The 5HT&lt;sub&gt;2&lt;\/sub&gt; receptor antagonist ketanserin (KT; 10\u2013\u20135\u201310\u2013\u20134M) and mixed 5HT&lt;sub&gt;1&lt;\/sub&gt;\/5HT&lt;sub&gt;2&lt;\/sub&gt; receptor antagonist methysergide (MS; 5 \u00d7 10\u2013\u20135M) inhibited the effect of 5-HT. Since the antagonist dissociation constant at 5HT&lt;sub&gt;2&lt;\/sub&gt; receptors for both KT and MS is found to be approximately 10\u2013\u20139M, it is concluded that this contractile effect may have been mediated by some other, as yet uncharac-terized 5-HT receptor. We believe that 5-HT is a potential neurotransmitter in the human upper ureteral smooth muscle.<\/jats:p>","DOI":"10.1159\/000282786","type":"journal-article","created":{"date-parts":[[2010,2,4]],"date-time":"2010-02-04T10:32:04Z","timestamp":1265279524000},"page":"202-204","source":"Crossref","is-referenced-by-count":9,"title":["Influence of Serotonin on the Human Ureter: An in vitro Pharmacological Study"],"prefix":"10.1159","author":[{"given":"Sedef","family":"Gidener","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziya","family":"Kirkali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fclya","family":"G\u00fcven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,2,3]]},"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000282786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:01:46Z","timestamp":1777568506000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000282786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000282786","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,3]]}}}