{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:39:31Z","timestamp":1745469571840,"version":"3.40.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2010]]},"abstract":"In order to clarify the immunological characteristics of multiple sclerosis (MS) and neuromyelitis optica (NMO), we analyzed CD3, CD4, CD8, CD20, CD4<sup>+<\/sup>CD25<sup>+<\/sup>, CD4<sup>+<\/sup>CD29<sup>+<\/sup>, and CD8<sup>+<\/sup>CD11a<sup>high<\/sup> cells in peripheral blood from patients with MS (16 stable, 6 active) and NMO (15 stable, 7 active), as well as 9 with NMO spectrum, 6 with clinically isolated syndrome (CIS), and 13 with other neurological diseases using flow cytometry. Significant decreases in the numbers of CD8<sup>+<\/sup> CD11a<sup>high<\/sup> cells were observed in stable and active MS and CIS. Our findings indicate that CD8<sup>+<\/sup>CD11a<sup>high<\/sup> cells play different roles in MS and NMO, and their presence may be related to the pathogenesis of MS from the early stage.<\/jats:p>","DOI":"10.1159\/000283929","type":"journal-article","created":{"date-parts":[[2010,2,16]],"date-time":"2010-02-16T09:43:30Z","timestamp":1266313410000},"page":"159-163","source":"Crossref","is-referenced-by-count":1,"title":["CD8<sup>+<\/sup>CD11a<sup>high<\/sup> Cells Decreased in Multiple Sclerosis but Not in Neuromyelitis Optica"],"prefix":"10.1159","volume":"63","author":[{"given":"Masaru","family":"Matsui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Tahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,2,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-510X%2881%2990083-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2804%2917551-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20050304"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000216139.44259.74"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2800%2900456-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2802%2900352-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.57.8.1183"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00856808"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00858721"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.1995.tb00147.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.1032"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2807%2970216-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1177%2F1352458507076976"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2249.2003.02291.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2F330479a0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawm047"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawl371"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00401-006-0169-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177%2F13524585070130030201"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-005-0778-z"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410190610"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1006%2Fsmim.1999.0168"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-4547%2819960815%2945%3A4%3C349%3A%3AAID-JNR4%3E3.0.CO%3B2-9"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0166-2236%2802%2902154-9"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F123.6.1174"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawf235"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000254502.87233.9a"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/283929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/283929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:08:45Z","timestamp":1745438925000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000283929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000283929","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"type":"print","value":"0014-3022"},{"type":"electronic","value":"1421-9913"}],"subject":[],"published":{"date-parts":[[2010]]}}}