{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:39:32Z","timestamp":1745469572764,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background:<\/i> A significant patent ductus arteriosus (PDA) is a common finding in the first days of life and, if persistent, is associated with an increased morbidity and mortality in the preterm newborn. <i>Objectives:<\/i> Our aim was to investigate, using near-infrared spectroscopy, the effect of indomethacin on the fractional tissue (cerebral) oxygen extraction (FT<sub>c<\/sub>OE) in a group of preterm newborns undergoing medical treatment for a PDA. <i>Methods:<\/i> This is a prospective, observational study. A cohort of 18 preterm newborns (<32 weeks) undergoing treatment for a PDA with indomethacin were monitored continuously for mean arterial blood pressure, arterial oxygen saturation (SpO<sub>2<\/sub>) and regional cerebral oxygen saturation (r<sub>c<\/sub>SO<sub>2<\/sub>). Measurements were started 1 h before and continued for 4 h after the first indomethacin dose. A final measurement (1 h) was made within 24 h of completing the full course. FT<sub>c<\/sub>OE = [SpO<sub>2<\/sub> \u2013 r<sub>c<\/sub>SO<sub>2<\/sub>]\/SpO<sub>2<\/sub> was then calculated. To analyze the data, we chose to average the measurements over 1-hour periods. <i>Results:<\/i> There was a significant increase in the FT<sub>c<\/sub>OE (0.06, 95% CI 0.04\u20130.09, p < 0.001) noticeable within the 1st hour after the start of indomethacin administration, which peaked in the 2nd hour (FT<sub>c<\/sub>OE increased by 0.08, 95% CI 0.04\u20130.11, p < 0.001) and lasted for the full 4-hour period measured. <i>Conclusion:<\/i> Indomethacin, infused over 30 min, significantly increased the FT<sub>c<\/sub>OE in the preterm newborn, the effect lasting at least 4 h. This may represent a protective response to the indomethacin-induced reduction in cerebral blood flow demonstrated by others and warrants further investigation.<\/jats:p>","DOI":"10.1159\/000283946","type":"journal-article","created":{"date-parts":[[2010,4,13]],"date-time":"2010-04-13T07:54:18Z","timestamp":1271145258000},"page":"232-237","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Indomethacin Infused over 30 Minutes on Cerebral Fractional Tissue Oxygen Extraction in Preterm Newborns with a Patent Ductus Arteriosus"],"prefix":"10.1159","volume":"98","author":[{"given":"Paul","family":"Keating","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Verhagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacorina","family":"van Hoften","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk","family":"ter Horst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arend F.","family":"Bos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,4,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2882%2980715-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2881%2980408-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2805%2980662-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F080352502317371698"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.64.1_Spec_No.8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00221-006-0388-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000101063"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0005-2728%2888%2990069-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000101063"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00442705"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2890%2993030-S"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00246-007-9166-z"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2007-0925"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2805%2983342-6"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/283946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/283946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:08:54Z","timestamp":1745438934000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000283946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,9,1]]},"published-print":{"date-parts":[[2010,9,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000283946","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2010]]}}}