{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:04:05Z","timestamp":1766268245030,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; To explore the relationship between magnetic resonance imaging (MRI) findings and multiple pituitary-target hormones in patients with panhypopituitarism or multiple pituitary hormone deficiency (MPHD). &lt;i&gt;Methods:&lt;\/i&gt; 125 patients with MPHD (102 boys, MPHD group) and 90 age-, sex- and Tanner stage-matched normal children (control group) were enrolled. 96 of the patients with MPHD underwent MRI scans of the hypothalamic-pituitary area. The patients were subdivided into five stages according to their MRI findings. The serum concentrations of GH, IGF-1, FT&lt;sub&gt;4&lt;\/sub&gt;, TSH, ACTH, cortisol, FSH, LH, prolactin, testosterone and estradiol were measured in patients and in controls. &lt;i&gt;Results:&lt;\/i&gt; MRI stage was significantly positively correlated with the number of pituitary hormone deficiencies (r = 0.9, p &lt; 0.001). MRI stage was negatively correlated with peak GH, IGF-1, FT&lt;sub&gt;4&lt;\/sub&gt;, cortisol and anterior pituitary height (r = \u20130.43, \u20130.47, \u20130.67, \u20130.54, and \u20130.49, respectively, p &lt; 0.01). Diabetes insipidus patients could be stratified according to their MRI stage; diabetes insipidus was found mainly in patients with absence of the posterior pituitary bright spot or small ectopic posterior pituitary bright spot on MRI. &lt;i&gt;Conclusion:&lt;\/i&gt; An abnormal MRI finding is evidence of MPHD and, correspondingly, there is a noteworthy correlation between MRI and pituitary function.<\/jats:p>","DOI":"10.1159\/000284363","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T08:01:26Z","timestamp":1267603286000},"page":"205-209","source":"Crossref","is-referenced-by-count":10,"title":["Magnetic Resonance Imaging and Pituitary Function in Children with Panhypopituitarism"],"prefix":"10.1159","volume":"73","author":[{"given":"Guimei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,3,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000089425"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2007-2648"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2007.03155.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00247-005-1512-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000181823"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1430493"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.4.1324"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.6.1954"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000080761"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.2003.01892.x"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/284363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/284363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:13:50Z","timestamp":1745439230000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000284363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000284363","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2010]]}}}