{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:05:37Z","timestamp":1777946737815,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T00:00:00Z","timestamp":1265760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T00:00:00Z","timestamp":1265760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopathology"],"abstract":"<jats:p>Clinical and preclinical data suggest a link between serotonin [5-hydroxytryptamine (5-HT)] function and certain psychopathologic dimensions of anxiety disorders. Anti-depressants consistently have been found to exert a favorable effect in anxiety disorders, particularly panic disorders. Clinical studies with 5-HT-selective drugs have shown that 5-HT neurons may comprise the site at which anxiolytic drugs exert a significant proportion of their action. Thus, fluvoxamine, a selective 5-HT uptake inhibitor, but not maprotiline, a selective noradrenaline uptake inhibitor, was found to be efficacious in panic disorder. The clinical effect of fluvoxamine revealed a noteworthy time course. After an initial increase in anxiety, improvement was attained gradually. On the basis of this finding, we tentatively hypothesized that stimulation of the 5-HT receptors, resulting from uptake inhibition, would worsen the condition of the patient, while down-regulation of the 5-HT receptors, resulting from chronic treatment, would account for the clinical efficacy. Thus, we performed a study in which ritanserin, a putative 5-HT&lt;sub&gt;2&lt;\/sub&gt; antagonist, was compared with fluvoxamine. Ritan-serin was found to be ineffective in the treatment of panic disorder symptoms, suggesting that 5-HT&lt;sub&gt;2&lt;\/sub&gt; receptors may not be critically involved in the mechanism underlying the anxiolytic activity of 5-HT uptake inhibitors. It would seem, therefore, that other 5-HT-receptor subtypes, e.g., 5-HT&lt;sub&gt;1&lt;\/sub&gt; may be implicated in this effect. Recent studies with selective 5-HT&lt;sub&gt;1&lt;\/sub&gt; agonists support this hypothesis.<\/jats:p>","DOI":"10.1159\/000284628","type":"journal-article","created":{"date-parts":[[2010,2,11]],"date-time":"2010-02-11T03:02:37Z","timestamp":1265857357000},"page":"68-77","source":"Crossref","is-referenced-by-count":24,"title":["Serotonin-Influencing Drugs in the Treatment of Panic Disorder"],"prefix":"10.1159","author":[{"given":"Herman G.M.","family":"Westenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan A.","family":"den Boer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,2,10]]},"container-title":["Psychopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000284628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T20:16:59Z","timestamp":1777753019000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000284628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,10]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000284628","archive":["Portico"],"relation":{},"ISSN":["0254-4962","1423-033X"],"issn-type":[{"value":"0254-4962","type":"print"},{"value":"1423-033X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,10]]}}}