{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:39:56Z","timestamp":1745469596057,"version":"3.40.4"},"reference-count":31,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background\/Objective:&lt;\/i&gt; Acne vulgaris exhibits a worldwide prevalence of up to 95% among adolescents. On the other hand, Down syndrome is an autosomal chromosomal disorder with associated dermatoses and a tendency to obesity. There are no data on its association with acne. Our aim was to detect the prevalence of acne, its forms and associated factors in Down syndrome. &lt;i&gt;Method:&lt;\/i&gt; A cross-sectional study including 89 subjects aged 10\u201328 years from Associa\u00e7\u00e3o de Pais e Amigos dos Excepcionais-S\u00e3o Paulo to verify acne, metabolic and hormonal disorders by interview, clinical and laboratory examinations. &lt;i&gt;Results:&lt;\/i&gt; We evaluated 49 (55%) males and 40 (45%) females. A weak agreement between self-estimation for acne and examination result was detected. The overall prevalence of acne was 70.8%: 83.7% in males and 55% in females. The prevalence of acne in the age groups 10\u201317 and 18\u201328 was 62 and 78.7%, respectively. Facial comedonal acne was mostly detected. The prevalence of obesity was 40%, that of metabolic disorders 7% and that of hyperandrogenism (in females) 15%. Except for gender, no other factor evaluated correlated with acne. &lt;i&gt;Conclusion:&lt;\/i&gt; A low prevalence of acne in Down syndrome, a predominance in males aged 18\u201328 and a facial comedonal form were detected. An association with obesity, metabolic disorders or hyperandrogenemia was not assessed.<\/jats:p>","DOI":"10.1159\/000284680","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T07:55:41Z","timestamp":1269330941000},"page":"333-339","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence of Acne Vulgaris in Patients with Down Syndrome"],"prefix":"10.1159","volume":"220","author":[{"given":"Edileia","family":"Bagatin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristhine Souza Le\u00e3o","family":"Kamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilia Ramos","family":"dos Santos 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