{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:44:28Z","timestamp":1781174668137,"version":"3.54.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Objective:<\/i> To characterize the frequency of genetic profiles in pediatric acute lymphoblastic leukemia (ALL) patients in Kuwait. <i>Subjects and Methods:<\/i> This review presents the general cytogenetic characteristics of 164 pediatric patients diagnosed as having ALL in a 6-year period. Chromosomal and fluorescence in situ hybridization studies were made on bone marrow aspirates at diagnosis and during different stages of the disease. <i>Results:<\/i> Recurring aberrations, observed in 123 (75%) patients, included hyperdiploidy (n = 68, 41%), tetraploidy (n = 12, 7.3%), hypodiploidy (n = 2, 1.2%), <i>TEL-AML1<\/i> fusion (n = 11, 7%), mixed-lineage leukemia rearrangement (n = 6, 3.6%), t(9;22) (n = 4, 2.4%), t(1;19) (n = 3, 1.8%), t(8;14) or t(8;22) (n = 2, 1.2%), +21 (n = 2, 1.2%), del(6) (n = 2, 1.2%) and miscellaneous abnormalities (n = 9, 5%). The highest observed numerical chromosome abnormality was high hyperdiploidy in 89 patients (54%) with abnormal karyotype while the <i>TEL-AML<\/i> fusion was the highest observed structural abnormality. <i>Conclusion:<\/i> This study showed that clonal anomalies detected in pediatric ALL have shown correlations between specific abnormalities and clinicobiological characteristics of the patients.<\/jats:p>","DOI":"10.1159\/000285281","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T07:11:08Z","timestamp":1269933068000},"page":"176-181","source":"Crossref","is-referenced-by-count":4,"title":["Frequency and Type of Chromosomal Abnormalities in Childhood Acute Lymphoblastic Leukemia Patients in Kuwait: A Six-Year Retrospective Study"],"prefix":"10.1159","volume":"19","author":[{"given":"Soad","family":"Al-Bahar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Z\u00e1me\u010dn\u00edkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Pandita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,3,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra023001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182%2Fasheducation-2003.1.102"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mph.0000212972.90877.28"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F10428190600799888"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fpbc.21129"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2002-02-0395"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.290.15.2001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0609.2000.90190.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood.V97.5.1211"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2004-04-1616"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-12-064642"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2006.06337.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2400989"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fpbc.20193"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2003-10-3446"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2400651"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2005-08-3451"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2005-07-2930"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2003-01-0338"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2007-01-068478"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/285281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/285281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:23:10Z","timestamp":1745439790000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000285281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000285281","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}