{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:13:50Z","timestamp":1789863230452,"version":"4.0.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"1-3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Sporadic forms of Alzheimer\u2019s and Parkinson\u2019s diseases are the most frequent forms of their kind. Together with Huntington\u2019s disease, they belong to the so called \u2018conformational diseases\u2019 as they share a common feature in the accumulation of insoluble protein deposits. In this review, we focus on the significance of the ubiquitin-proteasome system in conformational diseases and the possible consequences due to the accumulation of aberrant proteins. In all forms of Alzheimer\u2019s and Huntington\u2019s diseases, but not in Parkinson\u2019s disease, we have shown the presence of misframed proteins such as misframed ubiquitin (UBB&lt;sup&gt;+1&lt;\/sup&gt;) of which we have determined the functional relevance in vitro and in vivo.Misframed proteins are the result of the inaccurate transcription of monotonic sequences in the genome and their subsequent translation. This process has been called \u2018molecular misreading\u2019. In the present review, we will discuss the present state of the art with regard to UBB&lt;sup&gt;+1&lt;\/sup&gt; and amyloid precursor protein APP&lt;sup&gt;+1&lt;\/sup&gt;.<\/jats:p>","DOI":"10.1159\/000285510","type":"journal-article","created":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T11:28:13Z","timestamp":1266492493000},"page":"76-79","source":"Crossref","is-referenced-by-count":16,"title":["Misframed Proteins and Neurodegeneration: A Novel View on Alzheimer\u2019s and Parkinson\u2019s Diseases"],"prefix":"10.1159","volume":"7","author":[{"given":"F.J.A.","family":"Dennissen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kholod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.W.M.","family":"Steinbusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.W.","family":"Van Leeuwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,2,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2808%2961075-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2F459310a"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature07767"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.279.5348.242"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2004.03.011"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.03-0205com"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.pharmtox.051208.165340"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.cdd.4402180"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1242%2Fjcs.03438"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.200111034"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M807554200"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.08-115055"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neulet.2009.05.074"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0905746106"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Femboj.2009.115"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2Fddh188"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000193882.46003.6d"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2008.06.009"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2007.02.047"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M302295200"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.2004.02528.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2005.09.010"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/285510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/285510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:25:27Z","timestamp":1745439927000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000285510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":22,"journal-issue":{"issue":"1-3","published-online":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000285510","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}