{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:03:03Z","timestamp":1790823783793,"version":"4.1.0"},"reference-count":43,"publisher":"S. Karger AG","issue":"1-3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Alzheimer\u2019s disease (AD) is a neurodegenerative disease characterized by progressive memory loss, possibly triggered by the accumulation of \u03b2-amyloid (A\u03b2) peptides and the hyperphosphorylation of Tau neurofilament protein. Recent findings have shown that transthyretin (TTR) is a potent scavenger of A\u03b2 peptide deposits, suggesting a possible neuroprotective role for TTR in neurodegenerative processes associated with amyloidogenesis, such as AD. &lt;i&gt;Methods:&lt;\/i&gt; To investigate the relationship between TTR and A\u03b2 deposition, we crossed mouse carrying a deletion of TTR (TTR&lt;sup&gt;\u2013\/\u2013&lt;\/sup&gt;) with a transgenic mouse model of AD (TgCRND8), and A\u03b2 burden and spatial learning capacities were evaluated at 4 and 6 months of age (exclusion of the 6 month-old TgCRND8\/TTR&lt;sup&gt;\u2013\/\u2013&lt;\/sup&gt; group due to low survival rate). &lt;i&gt;Results:&lt;\/i&gt; Rather surprisingly, A\u03b2 plaque burden was significantly reduced in the hippocampus of 4-month-old TgCRND8\/TTR&lt;sup&gt;+\/\u2013&lt;\/sup&gt;, and to a lesser extent in TgCRND8\/TTR&lt;sup&gt;\u2013\/\u2013&lt;\/sup&gt;, as compared to age-matched TgCRND8\/TTR&lt;sup&gt;+\/+&lt;\/sup&gt;. No difference in plaque burden was found between any groups in 6-month-old animals. At 4 and 6 months of age, all populations of these hybrid transgenic mice displayed similar magnitude of spatial memory deficits in the Morris water maze task. &lt;i&gt;Conclusion:&lt;\/i&gt; Since TgCRND8 mice represent an aggressive model of A\u03b2 deposition with plaques developing as early as 3 months of age, along with spatial learning deficits, it may be already too late at 4 and 6 months of age to observe significant changes due to the deletion of the TTR gene.<\/jats:p>","DOI":"10.1159\/000285513","type":"journal-article","created":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T11:28:13Z","timestamp":1266492493000},"page":"88-95","source":"Crossref","is-referenced-by-count":12,"title":["Possible Involvement of Transthyretin in Hippocampal \u03b2-Amyloid Burden and Learning Behaviors in a Mouse Model of Alzheimer\u2019s Disease (TgCRND8)"],"prefix":"10.1159","volume":"7","author":[{"given":"Sihem","family":"Doggui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Brouillette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Guy","family":"Chabot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Farso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Quirion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,2,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1132814"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0447.2003.00081.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F122.3.383"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawg236"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1072994"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.emboj.7600061"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.2006.04426.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F4.12.2373"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2F375754a0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2007.04.007"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nlm.2007.07.006"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.130.2.933"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm793"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2005.09.039"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.febslet.2008.02.034"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.91.18.8368"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080%2F13506120410001667458"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2006.03.015"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0712197105"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1523%2FJNEUROSCI.2211-04.2004"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cell.2005.01.015"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2F0304-3940%2896%2912334-X"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neurobiolaging.2009.02.014"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1179%2F016164106X98035"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mad.2005.09.021"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.21038"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000312383.39973.88"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-5793%2898%2900234-8"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.63.4.506"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M100710200"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jneuroim.2004.04.014"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.90.6.2375"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-0270%2884%2990007-4"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbr.2004.12.017"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1038%2F35050110"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007%2FPL00000791"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroscience.2008.12.045"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.92.20.9368"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clinbiochem.2005.08.007"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1523%2FJNEUROSCI.1919-07.2007"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1750-3639.2008.00166.x"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2Fddh019"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.94.24.13287"}],"container-title":["Neurodegenerative 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