{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:01:11Z","timestamp":1777946471164,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,2,12]],"date-time":"2010-02-12T00:00:00Z","timestamp":1265932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,2,12]],"date-time":"2010-02-12T00:00:00Z","timestamp":1265932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychother Psychosom"],"abstract":"<jats:p>Graphically documented clinical observations and quantitative evaluations are reported of two longitudinal studies involving one case of Tourette\u2019s Disease and twenty-five acute schizophrenics treated by high potency neuroleptics. The findings indicate that symptoms expressing disfunction of the dopaminergic nigro-striatal system seem to be drug and dosage related, while those expressing dysfunction of hypothalamic integration (nor-adrenergic) seem to be related to factors other than neuroleptic drugs. Supporting evidence is cited from the literature pointing out a possible existence of at least two levels of \u2018central\u2019 integration. It is assumed that a functional dysharmony or a split between such levels may be cause, effect or concommittant of psychosomatic disease.<\/jats:p>","DOI":"10.1159\/000286071","type":"journal-article","created":{"date-parts":[[2010,2,15]],"date-time":"2010-02-15T06:48:17Z","timestamp":1266216497000},"page":"130-136","source":"Crossref","is-referenced-by-count":0,"title":["Man\u2019s Tripartite Brain and Psychosomatic Medicine"],"prefix":"10.1159","author":[{"given":"W.","family":"Knopp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,2,12]]},"container-title":["Psychotherapy and Psychosomatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000286071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T17:36:27Z","timestamp":1777743387000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000286071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,12]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000286071","archive":["Portico"],"relation":{},"ISSN":["0033-3190","1423-0348"],"issn-type":[{"value":"0033-3190","type":"print"},{"value":"1423-0348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,12]]}}}