{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:33Z","timestamp":1787017893349,"version":"build-2736575974"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Up to 20% of lacunar infarcts are clinically misdiagnosed as cortical infarcts and vice versa. The reasons for this discrepancy are unclear. We assessed clinical and imaging features which might explain this \u2018clinical-imaging dissociation\u2019 (C-ID). &lt;i&gt;Methods:&lt;\/i&gt; Patients with an acute stroke syndrome (cortical or lacunar) underwent magnetic resonance imaging including diffusion-weighted imaging (DWI). We recorded DWI-positive infarcts and proximity to cortex for small subcortical infarcts. We examined factors associated with C-ID. &lt;i&gt;Results:&lt;\/i&gt; 137 patients with a mild cortical or lacunar syndrome had an acute ischemic lesion on DWI. Of these, 21\/93 (23%) with a cortical syndrome had an acute lacunar infarct and 7\/44 (16%) with a lacunar syndrome had an acute cortical infarct. From 72 patients with an acute lacunar infarct on DWI, lesion proximity to cortex (odds ratio (OR) 14.5, 95% confidence interval (CI) 1.61\u2013130.1), left hemisphere location (OR 8.95, 95% CI 1.23\u201364.99) and diabetes (OR 17.1, 95% CI 1.49\u2013196.16) predicted C-ID. On multivariate analysis of all 137 patients, C-ID was associated with diabetes (OR 7.12, 95% CI 1.86\u201327.2). &lt;i&gt;Conclusions:&lt;\/i&gt; C-ID occurs in a fifth of patients with mild stroke. Lacunar infarcts lying close to cortex are more likely to cause cortical symptoms. Diabetes is associated with any clinical-imaging mismatch. Stroke misclassification which can arise with clinical classification alone should be minimized in research by verification with high-sensitivity imaging.<\/jats:p>","DOI":"10.1159\/000286342","type":"journal-article","created":{"date-parts":[[2010,2,19]],"date-time":"2010-02-19T02:45:10Z","timestamp":1266547510000},"page":"395-402","source":"Crossref","is-referenced-by-count":66,"title":["Associations of Clinical Stroke Misclassification (\u2018Clinical-Imaging Dissociation\u2019) in Acute Ischemic Stroke"],"prefix":"10.1159","volume":"29","author":[{"given":"Gillian","family":"Potter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus","family":"Doubal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathie","family":"Sudlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Wardlaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000210432"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2891%2993206-O"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.68.5.558"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1052-3057%2898%2980052-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053%2Fjscd.2003.7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1351-5101.2003.00712.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.108.526772"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.67.5.682"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.57.10.1173"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.30.12.2644"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0404.2000.101002128.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.74.7.886"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2005.063594"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000158908.48022.d7"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000196817"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2807%2960151-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fqjmed%2Fhcm152"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2003.030858"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00330-008-1119-2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.74.6.734"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177%2F1051228404263277"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.74.4.452"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159%2F000047729"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000131930.41057.48"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2896%2909457-3"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/286342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/286342","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/286342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:35:09Z","timestamp":1745426109000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000286342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000286342","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5121046","asserted-by":"subject"}]},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}