{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:06:39Z","timestamp":1778043999913,"version":"3.51.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background:<\/i> Cigarette smoke (CS) is the major risk factor for aerodigestive tract cancers such as lung and oral cancers. <i>Methods:<\/i> In in vitro models of lung and oral cancers, we found <i>D<\/i>-penicillamine (PenA) to be a most potent protector against CS, both in the absence and presence of saliva (a highly pro-oxidative condition). <i>Results:<\/i> The survival rate of lung cancer cells and oral cancer cells was reduced by CS in the absence of saliva by 39\u201345% (p < 0.01) and by 55\u201360% (p < 0.01) in the presence of saliva. The addition of 5 m<i>M<\/i> PenA to cell medium prior to CS exposure limited cell loss to 22\u201325% only (p < 0.01). Similarly, the iron chelator desferal protected the cells only in the presence of saliva. PenA also protected against a CS-induced increase in carbonyls (oxidized proteins) and decrease in p53 levels (in the presence of saliva) and mitochondrial membrane potential (a hallmark of CS-induced apoptotic cell death). Malfunctioning p53 often characterizes carcinogenesis of CS-induced cancers. <i>Conclusions:<\/i> Redox-active iron and copper in pleural fluid and saliva, upon encounter with CS, may be responsible for this carcinogenesis, mediated via alteration of p53 function. Chelation of redox-active metals may be an efficient tool for prevention of CS-induced lung and oral cancers. The superiority of PenA results from its copper-chelating action as well as its antialdehyde and anti-inflammatory capabilities.<\/jats:p>","DOI":"10.1159\/000287967","type":"journal-article","created":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T09:20:08Z","timestamp":1267435208000},"page":"12-19","source":"Crossref","is-referenced-by-count":8,"title":["Penicillamine as a Potent Protector against Injurious Effects of Cigarette Smoke in Aerodigestive Tract Cancer"],"prefix":"10.1159","volume":"78","author":[{"given":"Rafael","family":"Nagler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiri","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Savulescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Leschiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Otradnov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Gavish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1054%2Fbjoc.2000.1323"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0194-5998%2800%2970142-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fhed.20091"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.biocel.2003.09.003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6601869"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1006%2Fabbi.2000.1877"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2307%2F3579504"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000196511"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.1996.0518"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1006%2Fabio.1976.9999"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0076-6879%2894%2933040-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1179%2F135100099101534945"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080%2F08958370600742821"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0607031103"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fjnr.21360"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00213-005-0224-z"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejphar.2007.10.066"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093%2Frheumatology%2F36.1.104"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1165%2Frcmb.2006-0047SF"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/287967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/287967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:41:43Z","timestamp":1745437303000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000287967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000287967","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}