{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:10:12Z","timestamp":1745439012413,"version":"3.40.4"},"reference-count":40,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Using a T helper (Th)1\/Th2 disease model, we previously showed that genetically determined Th development depends on dendritic cell-derived interleukin (IL)-1\u03b1. In &lt;i&gt;Leishmania major&lt;\/i&gt; infections, Th1 immunity develops if IL-1\u03b1 is present during T cell priming, whereas at later time points, IL-1\u03b1 worsens disease outcome. In the present study, we determined the role of IL-1\u03b1 in other Th2-mediated diseases. &lt;i&gt;Methods:&lt;\/i&gt; BALB\/c mice were subjected to delayed-type hypersensitivity (DTH) or ovalbumin (OVA)\/alum-induced allergic asthma in the presence or absence of IL-1\u03b1. &lt;i&gt;Results:&lt;\/i&gt; In DTH, mice treated with IL-1\u03b1 during sensitization with keyhole limpet hemocyanin (KLH)\/alum developed decreased footpad swelling associated with elevated KLH-specific interferon-\u03b3 levels. In asthma, significantly decreased airway hypersensitivity responses (AHRs) were detected upon treatment with IL-1\u03b1 during T cell priming. In contrast to control mice, IL-1\u03b1-treated mice showed reduced peribronchial inflammatory infiltrates. The bronchoalveolar lavage (BAL) fluid contained significantly decreased eosinophil numbers (approximately 50%), but 4 times more neutrophils. The BAL fluid of IL-1\u03b1-treated BALB\/c exhibited reduced amounts of IL-5 and OVA-specific IgE serum levels. In contrast, IL-1\u03b1 treatment at later time points after sensitization or during allergen challenge worsened AHR, had no effect on lung inflammation and BAL fluid cell composition. Furthermore, cytokine levels (IL-5, IL-13) and antigen-specific IgE were increased or unaltered under these conditions. &lt;i&gt;Conclusion:&lt;\/i&gt; Similarly to leishmaniasis, IL-1\u03b1 administration during sensitization of Th2-mediated allergic reactions suppresses the course of disease by shifting the immune response towards Th1, whereas later treatments worsen disease outcome. Future studies will elucidate the therapeutic value of IL-1\u03b1 in asthmatic patients.<\/jats:p>","DOI":"10.1159\/000288283","type":"journal-article","created":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T09:20:08Z","timestamp":1267435208000},"page":"303-312","source":"Crossref","is-referenced-by-count":10,"title":["Dual Role of Interleukin-1\u03b1 in Delayed-Type Hypersensitivity and Airway Hyperresponsiveness"],"prefix":"10.1159","volume":"152","author":[{"given":"Peri","family":"Caucig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Teschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Dinges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim 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