{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:58:55Z","timestamp":1780563535490,"version":"3.54.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Allergy to penicillins remains an important issue. Penicillin skin testing (PST) with major and minor determinants has been shown to be a highly valuable tool for identifying IgE-mediated penicillin allergy. The value of additional testing with side-chain-specific moieties from semisynthetic penicillins such as amoxicillin is not well-established in spite of the widespread use of these medications. &lt;i&gt;Methods:&lt;\/i&gt; A retrospective review of all consecutive inpatient PST results from 1995 to 2007 comprising 1,068 patients was performed in our institution on individuals with a self-reported history of beta-lactam allergy to assess the importance of including the amoxicillin determinant in a previously validated PST panel. Descriptive statistics were performed. The PST panel included penicilloyl-polylysine, penicillin G, penicilloate, penilloate and amoxicillin. &lt;i&gt;Results:&lt;\/i&gt; Of 1,068 patients, 243 (23%) had a positive skin test reaction on the PST panel. Testing with amoxicillin was positive in 30.9% of patients, the majority of whom (81%) were also positive to 1 or more standard penicillin reagents. Fourteen of the 243 positive patients (5.8%) had a positive skin test reaction only to amoxicillin. Additionally, the use of penicilloate and penilloate minor determinants in combination with penicillin G identified a greater percentage of penicillin-allergic individuals compared to using only penicillin G (22.6 vs. 6.6%), demonstrating their importance in the PST panel. &lt;i&gt;Conclusions:&lt;\/i&gt; These data indicate that the inclusion of the amoxicillin determinant appears to identify a small but important group of allergic individuals who may otherwise test negative on a PST panel.<\/jats:p>","DOI":"10.1159\/000288284","type":"journal-article","created":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T09:20:08Z","timestamp":1267435208000},"page":"313-318","source":"Crossref","is-referenced-by-count":40,"title":["Penicillin Allergy: Value of Including Amoxicillin as a Determinant in Penicillin Skin Testing"],"prefix":"10.1159","volume":"152","author":[{"given":"Erina","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Saxon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Riedl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,2,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2003.93"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.161.1.15"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2962466-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.270.20.2456"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2899%2970439-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1086%2F502212"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.160.18.2819"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2962782-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000230197"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2881%2990150-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2008.02960.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1988.tb01628.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.1990.tb03139.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2893%2990188-L"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000233659"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1994.tb02275.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.285.19.2498"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4065%2F80.3.405"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.152.5.1025"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2897%2970159-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fjps.2600580923"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2960621-7"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2881%2990180-9"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1592%2Fphco.27.4.542"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/288284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/288284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:45:22Z","timestamp":1745437522000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000288284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000288284","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}