{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:49:15Z","timestamp":1783471755904,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1159\/000288707","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T07:23:10Z","timestamp":1288336990000},"page":"603-612","source":"Crossref","is-referenced-by-count":13,"title":["Chronic Alcohol Intake Increases the Severity of Pancreatitis Induced by Acute Alcohol Administration, Hyperlipidemia and Pancreatic Duct Obstruction in Rats"],"prefix":"10.1016","volume":"10","author":[{"given":"J.","family":"Grauvogel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.D.","family":"Daemmrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ryschich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.","family":"Gebhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1159\/000288707_bib1","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0016-5085(90)90033-W","article-title":"Ethanol and the pancreas: current status","volume":"98","author":"Singh","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1159\/000288707_bib2","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1172\/JCI115091","article-title":"Apical secretion of lysosomal enzymes in rabbit pancreas occurs via a secretagogue regulated pathway and is increased after pancreatic duct obstruction","volume":"87","author":"Hirano","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1159\/000288707_bib3","doi-asserted-by":"crossref","first-page":"G65","DOI":"10.1152\/ajpgi.00419.2001","article-title":"Alcoholic pancreatitis in rats: injury from nonoxidative metabolites of ethanol","volume":"283","author":"Werner","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1159\/000288707_bib4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1136\/gut.38.5.753","article-title":"Hyperlipaemia intensifies the course of acute oedematous and acute necrotising pancreatitis in the rat","volume":"38","author":"Hofbauer","year":"1996","journal-title":"Gut"},{"key":"10.1159\/000288707_bib5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ng1096-141","article-title":"Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene","volume":"14","author":"Whitcomb","year":"1996","journal-title":"Nat Genet"},{"key":"10.1159\/000288707_bib6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/00006676-200010000-00009","article-title":"Cigarette smoke enhances ethanol-induced pancreatic injury","volume":"21","author":"Hartwig","year":"2000","journal-title":"Pancreas"},{"key":"10.1159\/000288707_bib7","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/S0016-5085(98)70097-6","article-title":"Pancreatic duct obstruction is an aggravating factor in the canine model of chronic alcoholic pancreatitis","volume":"115","author":"Tanaka","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1159\/000288707_bib8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S1091-255X(98)80075-9","article-title":"Ethanol inhibits sphincter of Oddi motility","volume":"2","author":"Tierney","year":"1998","journal-title":"J Gastrointest Surg"},{"key":"10.1159\/000288707_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s001040051046","article-title":"Changes in incidence and prevalence of acute and chronic pancreatitis in Germany (in German)","volume":"71","author":"Secknus","year":"2000","journal-title":"Chirurg"},{"key":"10.1159\/000288707_bib10","first-page":"G165","article-title":"Arterial constriction, ischemia-reperfusion, and leukocyte adherence in acute pancreatitis","volume":"265","author":"Kusterer","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1159\/000288707_bib11","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/bjs.1800771104","article-title":"Pancreatic ischaemia in experimental acute pancreatitis: mechanism, significance and therapy","volume":"77","author":"Klar","year":"1990","journal-title":"Br J Surg"},{"key":"10.1159\/000288707_bib12","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1161\/01.RES.50.2.250","article-title":"Ethanol-induced alterations in pancreatic blood flow in conscious dogs","volume":"50","author":"Horwitz","year":"1982","journal-title":"Circ Res"},{"key":"10.1159\/000288707_bib13","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1001\/archsurg.1995.01430040019001","article-title":"Alcohol selectively impairs oxygenation of the pancreas","volume":"130","author":"Foitzik","year":"1995","journal-title":"Arch Surg"},{"key":"10.1159\/000288707_bib14","first-page":"85","article-title":"Microcirculation of the pancreas: a quantitative study of physiology and changes in pancreatitis","volume":"9","author":"Klar","year":"1990","journal-title":"Int J Microcirc Clin Exp"},{"key":"10.1159\/000288707_bib15","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0076-6879(94)33061-1","article-title":"Animal models of chronic ethanol toxicity","volume":"233","author":"Lieber","year":"1994","journal-title":"Methods Enzymol"},{"key":"10.1159\/000288707_bib16","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000070085","article-title":"Oxygen radicals promote ICAM-1 expression and microcirculatory disturbances in experimental acute pancreatitis","volume":"3","author":"Keck","year":"2003","journal-title":"Pancreatology"},{"key":"10.1159\/000288707_bib17","first-page":"H1018","article-title":"Direct measurement of microvessel hematocrit, red cell flux, velocity, and transit time","volume":"243","author":"Sarelius","year":"1982","journal-title":"Am J Physiol"},{"key":"10.1159\/000288707_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/mvre.1995.1004","article-title":"Measurement of blood flow in pancreatic exchange capillaries with FITC-labeled erythrocytes","volume":"49","author":"Mithofer","year":"1995","journal-title":"Microvasc Res"},{"key":"10.1159\/000288707_bib19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1182\/blood.V83.2.345.345","article-title":"Reductions in physiologic shear rates lead to CD11\/CD18-dependent, selectin-independent leukocyte rolling in vivo","volume":"83","author":"Gaboury","year":"1994","journal-title":"Blood"},{"key":"10.1159\/000288707_bib20","first-page":"H847","article-title":"Molecular determinants of lipid mediator-induced leukocyte adherence and emigration in rat mesenteric venules","volume":"266","author":"Zimmerman","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1159\/000288707_bib21","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0076-6879(84)05055-2","article-title":"Antimicrobial activity of myeloperoxidase","volume":"105","author":"Klebanoff","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1159\/000288707_bib22","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J Invest Dermatol"},{"key":"10.1159\/000288707_bib23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF02927069","article-title":"Morphometric chararcteristics and homogeneity of a new model of acute pancreatitis in the rat","volume":"12","author":"Schmidt","year":"1992","journal-title":"Int J Pancreatol"},{"key":"10.1159\/000288707_bib24","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/0002-9343(74)90480-X","article-title":"Acute pancreatitis with hyperlipemia: evidence for a persistent defect in lipid metabolism","volume":"56","author":"Cameron","year":"1974","journal-title":"Am J Med"},{"key":"10.1159\/000288707_bib25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s001040050043","article-title":"New pathophysiologic knowledge about acute pancreatitis (in German)","volume":"71","author":"Klar","year":"2000","journal-title":"Chirurg"},{"key":"10.1159\/000288707_bib26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00006676-199701000-00006","article-title":"Similar morphological and intracellular biochemical changes in alcoholic acute pancreatitis and ischemic acute pancreatitis in rats","volume":"14","author":"Siech","year":"1997","journal-title":"Pancreas"},{"key":"10.1159\/000288707_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s535-002-8125-1","article-title":"Genetic risk factors in chronic pancreatitis","volume":"37","author":"Teich","year":"2002","journal-title":"J Gastroenterol"},{"key":"10.1159\/000288707_bib28","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/gut.9.5.557","article-title":"Effects of ethyl alcohol on sphincteric resistance at the choledochoduodenal junction in man","volume":"9","author":"Pirola","year":"1968","journal-title":"Gut"},{"key":"10.1159\/000288707_bib29","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1067\/msy.2001.113891","article-title":"Linkage of oxidative and nonoxidative ethanol metabolism in the pancreas and toxicity of nonoxidative ethanol metabolites for pancreatic acinar cells","volume":"129","author":"Werner","year":"2001","journal-title":"Surgery"},{"key":"10.1159\/000288707_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00006676-200311000-00010","article-title":"Pathophysiology of alcohol-induced pancreatic injury","volume":"27","author":"Saluja","year":"2003","journal-title":"Pancreas"},{"key":"10.1159\/000288707_bib31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/0002-9610(68)90139-6","article-title":"Microcirculatory dynamics in the normal and inflamed pancreas","volume":"115","author":"Anderson","year":"1968","journal-title":"Am J Surg"},{"key":"10.1159\/000288707_bib32","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/BF01798362","article-title":"Effects of intravenous ethanol on hepatic and pancreatic blood flow in dogs","volume":"33","author":"Kogire","year":"1988","journal-title":"Dig Dis Sci"},{"key":"10.1159\/000288707_bib33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF02803766","article-title":"Role of hypertriglyceridemia in the pathogenesis of experimental acute pancreatitis in rats","volume":"20","author":"Kimura","year":"1996","journal-title":"Int J Pancreatol"},{"key":"10.1159\/000288707_bib34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1056-8719(98)00026-4","article-title":"Ethanol administration delays recovery from acute pancreatitis induced by exocrine hyperstimulation","volume":"39","author":"Yuasa","year":"1998","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1159\/000288707_bib35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00006676-200311000-00004","article-title":"Animal and in vitro models of alcoholic pancreatitis: role of cholecystokinin","volume":"27","author":"Pandol","year":"2003","journal-title":"Pancreas"},{"key":"10.1159\/000288707_bib36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0039-6060(05)80228-4","article-title":"Detailed characterization of experimental acute alcoholic pancreatitis","volume":"117","author":"Nordback","year":"1995","journal-title":"Surgery"},{"key":"10.1159\/000288707_bib37","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/00006676-200311000-00005","article-title":"Animal model of alcoholic pancreatitis: role of viral infections","volume":"27","author":"Jerrells","year":"2003","journal-title":"Pancreas"},{"key":"10.1159\/000288707_bib38","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/bjs.1800710913","article-title":"Hyperlipi-daemia, alcohol abuse and acute pancreatitis","volume":"71","author":"Dickson","year":"1984","journal-title":"Br J Surg"},{"key":"10.1159\/000288707_bib39","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1001\/jama.1991.03460070086049","article-title":"The familial hyperchylomicronemia syndrome: new insights into underlying genetic defects","volume":"265","author":"Santamarina-Fojo","year":"1991","journal-title":"JAMA"},{"key":"10.1159\/000288707_bib40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF01318373","article-title":"Effects of chronic alcohol abuse on exocrine pancreatic secretion in man","volume":"30","author":"Rinderknecht","year":"1985","journal-title":"Dig Dis Sci"},{"key":"10.1159\/000288707_bib41","first-page":"G457","article-title":"Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis","volume":"246","author":"Watanabe","year":"1984","journal-title":"Am J Physiol"},{"key":"10.1159\/000288707_bib42","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0016-5085(97)70106-9","article-title":"Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol","volume":"113","author":"Werner","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1159\/000288707_bib43","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1097\/00006676-200305000-00018","article-title":"Oxygen radical production precedes alcohol-induced acute pancreatitis in rats","volume":"26","author":"Wittel","year":"2003","journal-title":"Pancreas"},{"key":"10.1159\/000288707_bib44","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0016-5085(82)80389-2","article-title":"Pancreatic acinar cell function and morphology in rats chronically fed an ethanol diet","volume":"82","author":"Singh","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1159\/000288707_bib45","first-page":"G171","article-title":"Effect of ethanol on cholecystokinin-stimulated zymogen conversion in pancreatic acinar cells","volume":"270","author":"Katz","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1159\/000288707_bib46","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0002-9440(10)62235-3","article-title":"Chronic alcohol consumption accelerates fibrosis in response to cerulein-induced pancreatitis in rats","volume":"166","author":"Deng","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1159\/000288707_bib47","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/00000658-199504000-00006","article-title":"Increased intrapancreatic trypsinogen activation in ischemia-induced experimental pancreatitis","volume":"221","author":"Mithofer","year":"1995","journal-title":"Ann Surg"},{"key":"10.1159\/000288707_bib48","first-page":"H1936","article-title":"Hemorrhagic hypotension induces arteriolar vasomotion and intermittent capillary perfusion in rat pancreas","volume":"267","author":"Vollmar","year":"1994","journal-title":"Am J Physiol"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390310800511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390310800511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T20:57:20Z","timestamp":1636750640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390310800511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S1424390310800511"],"URL":"https:\/\/doi.org\/10.1159\/000288707","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}