{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T12:53:42Z","timestamp":1769950422687,"version":"3.49.0"},"reference-count":40,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; The main purpose of the study was to determine whether the predicted age of onset of Huntington\u2019s disease (HD) affects cognitive function as measured by the Wechsler Adult Intelligence Scale-Revised (WAIS-R). The subscales and subtests, and their potential selectivity were examined in preclinical HD (30 mutation carriers and 34 noncarriers) with no motor or neuropsychiatric signs of HD. &lt;i&gt;Methods:&lt;\/i&gt; The predicted age of onset in mutation carriers was calculated by a regression equation allowing this group to be divided according to whether onset was predicted as within 12 years (HD+CLOSE) or longer than this (HD+DISTANT). &lt;i&gt;Results:&lt;\/i&gt; The HD+CLOSE group scored significantly lower on Verbal, Performance, and Full Scale IQ compared to noncarriers and performed significantly lower on 7 of the 11 WAIS-R subtests, with low average scores in language abilities, attention, abstract thinking, problem solving, visuospatial ability, and psychomotor speed. &lt;i&gt;Conclusion:&lt;\/i&gt; These low average scores affect general intelligence and functioning of HD+CLOSE carriers and are likely to reflect dysfunction of frontal cortex and frontostriatal circuits more than a decade before manifest symptoms. Our findings support a continuous linear model of slow cognitive decline in HD.<\/jats:p>","DOI":"10.1159\/000288775","type":"journal-article","created":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T06:58:14Z","timestamp":1271228294000},"page":"342-350","source":"Crossref","is-referenced-by-count":11,"title":["WAIS-R Features of Preclinical Huntington\u2019s Disease: Implications for Early Detection"],"prefix":"10.1159","volume":"29","author":[{"given":"Tarja-Brita","family":"Robins Wahlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria U.","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary A.","family":"Luszcz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard 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