{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:34:36Z","timestamp":1790001276158,"version":"4.0.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"1-3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Parkinson\u2019s disease (PD) is a progressive neurodegenerative condition characterized by an increasing loss of dopaminergic neurons resulting in motor dysfunction. However, cognitive impairments in PD patients are a common clinical feature that has gained increased attention. &lt;i&gt;Objective:&lt;\/i&gt; The purpose of the current study was to evaluate the effects of an MPTP-induced dopaminergic lesion in mice on social odor recognition (SOR) memory. &lt;i&gt;Methods:&lt;\/i&gt; Mice were acutely treated with MPTP and evaluated for memory impairments in the SOR assay and characterized using biochemical and immunohistochemical methods approximately 2 weeks later. &lt;i&gt;Results:&lt;\/i&gt; Here we demonstrate that SOR memory is sensitive to MPTP treatment and that it correlates with multiple measures of nigrostriatal integrity. MPTP treatment of C57BL\/6N mice produced a profound decrease in dopamine levels, dopamine transporter binding and tyrosine hydroxylase immunoreactivity in the striatum. These impairments in stratial dopaminergic function were blocked by pretreatment with the MAO-B inhibitor deprenyl. Changes in the dopaminergic system parallel those observed in SOR with MPTP treatment impairing recognition memory in the absence of a deficit in odor discrimination during learning. Deprenyl pretreatment blocked the MPTP-induced impairment of SOR memory. &lt;i&gt;Conclusion:&lt;\/i&gt; The use of the SOR memory model may provide a preclinical method for evaluating cognitive therapies for PD.<\/jats:p>","DOI":"10.1159\/000289227","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T08:01:26Z","timestamp":1267603286000},"page":"153-159","source":"Crossref","is-referenced-by-count":12,"title":["Social Odor Recognition: A Novel Behavioral Model for Cognitive Dysfunction in Parkinson\u2019s Disease"],"prefix":"10.1159","volume":"7","author":[{"given":"Michael M.","family":"Monaghan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Leddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Li Amy","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Albinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Kubek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menelas N.","family":"Pangalos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Reinhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Zaleska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Comery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,3,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00146965-200312000-00001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pneurobio.2008.09.004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000180516.69442.95"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.69.3.308"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1602%2Fneurorx.2.3.484"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2890%2990069-N"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1460-9568.2004.03586.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0166-4328%2801%2900309-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2FPL00007803"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00213-008-1294-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nbd.2008.05.008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbr.2007.05.007"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1037%2F0735-7044.98.5.908"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0361-9230%2897%2900452-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nbd.2008.07.015"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2893%2990860-P"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0278-5846%2888%2990054-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2890%2991055-L"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.96.5.2456"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbr.2006.04.025"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1006%2Fneur.1996.0041"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neures.2004.09.012"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/289227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/289227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:55:15Z","timestamp":1745438115000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000289227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":22,"journal-issue":{"issue":"1-3","published-online":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000289227","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}