{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:54:41Z","timestamp":1779933281950,"version":"3.53.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Objective:<\/i> Stressful exercise reduces the plasma pro-inflammatory cytokine concentration in response to lipopolysaccharide (LPS). The aim of this study was to clarify the mechanism of exhaustive exercise-induced suppression of the plasma tumor necrosis factor (TNF)-\u03b1 concentration in response to LPS. <i>Methods:<\/i> Male C3H\/HeN mice (n = 66) were randomized to treadmill running to exhaustion (Ex) or a sedentary (Non-Ex) condition. Monocytes and splenic macrophages were collected from some animals, and other animals were injected with LPS (1 mg\/kg) immediately after the exercise. The liver, lung and spleen tissues in the mice were removed 30 min after the LPS injection for determination of TNF-\u03b1 mRNA expression. Blood and tissue samples were collected for determination of TNF-\u03b1 and TNF receptors (TNFR) 1 h after the LPS injection. <i>Results:<\/i> Although there was a significant suppression in LPS-induced plasma TNF-\u03b1 in the Ex mice when compared to the Non-Ex mice (p < 0.01), soluble TNFR in plasma was not affected by the exercise. There was no change in cell-surface expression of Toll-like receptor 4 (TLR4) and in LPS-induced TNF-\u03b1 mRNA expression and TNFR content in tissues between the Ex and Non-Ex groups. Interestingly, TNF-\u03b1 contents in the liver, lung and spleen of the Ex mice were significantly lower than those of the Non-Ex group (p < 0.01, p < 0.01 and p < 0.05, respectively). <i>Conclusion:<\/i> These data suggest that exhaustive exercise-induced suppression of the plasma TNF-\u03b1 concentration despite LPS stimulation might depend on translation of TNF-\u03b1 in tissues.<\/jats:p>","DOI":"10.1159\/000290044","type":"journal-article","created":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T07:52:38Z","timestamp":1267775558000},"page":"279-286","source":"Crossref","is-referenced-by-count":29,"title":["Exhaustive Exercise Reduces Tumor Necrosis Factor-\u03b1 Production in Response to Lipopolysaccharide in Mice"],"prefix":"10.1159","volume":"17","author":[{"given":"Yohei","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Kawanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Shiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritsugu","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-1024839"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fssu.2980050606"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000237256"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1574-695X.2006.00075.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000107424"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fnri1391"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2001-13818"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0013-9351%2805%2980249-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-2478%2899%2900148-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2893%2990134-C"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2F364798a0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1249%2F01.MSS.0000145465.71269.10"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1113%2Fjphysiol.2004.081224"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-201X.2004.01343.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI118090"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-2478%2893%2990177-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00199431"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpcell.00572.2007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1113%2Fjphysiol.2003.058420"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2004-830334"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1249%2F00005768-199402000-00003"}],"container-title":["Neuroimmunomodulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/290044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/290044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:04:34Z","timestamp":1745438674000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000290044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,3,1]]},"published-print":{"date-parts":[[2010,3,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000290044","archive":["Portico"],"relation":{},"ISSN":["1021-7401","1423-0216"],"issn-type":[{"value":"1021-7401","type":"print"},{"value":"1423-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}