{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:33:30Z","timestamp":1778074410456,"version":"3.51.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG) is one of the most active antiproliferative compounds in a series of acyclic nucleoside phosphonates and is active in intraperitoneal P388 tumors in mice. &lt;i&gt;Methods:&lt;\/i&gt; We synthesized octadecyloxyethyl (ODE) and hexadecyloxypropyl esters of PMEG and compared their antiproliferative activity with unmodified PMEG in primary human fibroblasts and CaSki, Me-180 and HeLa human cervical cancer cell lines in vitro. &lt;i&gt;Results:&lt;\/i&gt; ODE-PMEG had excellent antiproliferative activity in vitro in this panel of human cervical cancers. We compared the effects of ODE-PMEG and ODE-cidofovir (ODE-CDV) in a solid tumor model using Me-180 human cervical cancer cell lines in athymic nude mice. Intratumoral injection of 25 \u00b5g of ODE-PMEG or 100 \u00b5g of ODE-CDV daily for 21 days followed by observation for 20\u201335 days resulted in near-complete disappearance of measurable cervical cancers. &lt;i&gt;Conclusion:&lt;\/i&gt; ODE-PMEG may be suitable for local or topical treatment of cervical dysplasia.<\/jats:p>","DOI":"10.1159\/000292582","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T08:50:29Z","timestamp":1268038229000},"page":"54-59","source":"Crossref","is-referenced-by-count":6,"title":["Antiproliferative Effects of Octadecyloxyethyl 9-[2-(Phosphonomethoxy)Ethyl]Guanine against Me-180 Human Cervical Cancer Cells in vitro and in vivo"],"prefix":"10.1159","volume":"56","author":[{"given":"Nadejda","family":"Valiaeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julissa","family":"Trahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy A.","family":"Aldern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Beadle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl Y.","family":"Hostetler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,3,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1158%2F1535-7163.MCT-05-0200"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1205006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-9071%28199803%2954%3A3%3C219%3A%3AAID-JMV13%3E3.0.CO%3B2-C"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.46.8.2381-2386.2002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.46.4.991-995.2002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1086%2F426831"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.49.2.656-662.2005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1124%2Fmol.63.3.678"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.01223-05"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.01172-07"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.antiviral.2009.01.005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.antiviral.2006.03.007"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F82.6.510"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.273.34.21966"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-08-2848"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.00103-09"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/292582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/292582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:41:08Z","timestamp":1745437268000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000292582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000292582","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}