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In order to identify genes which could be deregulated in diffuse large B cell lymphomas (DLBCL), we analyzed the expression levels of genes mapped on chromosome 11q21\u2013qter across a series of publicly available DLBCL expression data sets. We identified &lt;i&gt;HTR3A,&lt;\/i&gt; the gene coding for 5-hydroxytryptamine receptor 3A, as the most frequently differentially expressed. Since HTR3A expression had not been previously characterized in normal and neoplastic B cells, we evaluated its expression by real-time PCR and by immunohistochemistry. The gene is expressed by B cells and it seems to be regulated during the mature B cell differentiation, being overexpressed during the germinal center phase. Lymphomas derived from germinal center B cells maintain the expression, with the level of expression varying among different patients.<\/jats:p>","DOI":"10.1159\/000292646","type":"journal-article","created":{"date-parts":[[2010,5,28]],"date-time":"2010-05-28T09:24:26Z","timestamp":1275038666000},"page":"129-135","source":"Crossref","is-referenced-by-count":29,"title":["Serotonin Receptor 3A Expression in Normal and Neoplastic B Cells"],"prefix":"10.1159","volume":"77","author":[{"given":"Andrea","family":"Rinaldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Chiaravalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Zucca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Tibiletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Capella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bertoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood.V99.1.3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.1999.01257.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2003.04763.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fgcc.20159"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejca.2007.02.005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.3457468"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1210637"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm0102-68"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.194.11.1625"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2003-06-1841"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdi217"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080%2F10428190601026562"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2003-05-1545"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0437996100"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1517%2F14728222.11.4.527"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080%2F03009740410006943"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080%2F03009740410006952"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bcp.2005.04.031"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2899%2900101-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1042%2F0264-6021%3A3440199"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1006%2Fcimm.1995.1092"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.85.12.4557"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2002-07-2044"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/292646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/292646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:41:31Z","timestamp":1745437291000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000292646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,5,1]]},"published-print":{"date-parts":[[2010,6,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000292646","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"value":"1015-2008","type":"print"},{"value":"1423-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}