{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:11:14Z","timestamp":1783944674415,"version":"3.55.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,3,2]],"date-time":"2010-03-02T00:00:00Z","timestamp":1267488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,3,2]],"date-time":"2010-03-02T00:00:00Z","timestamp":1267488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"abstract":"<jats:p>Labor characteristics after intracervical application of 0.5 mg prostaglandin (PG) E&lt;sub&gt;2&lt;\/sub&gt; gel (n = 83) versus intravenous administration of oxytocin (n = 82) for labor induction were investigated in uncomplicated prolonged pregnancies with unripe cervix. The induction to delivery time as well as the total oxytocin dose were significantly reduced in the PGE&lt;sub&gt;2&lt;\/sub&gt; group (p &lt; 0.001). Cesarean sections, instrumental deliveries and fetal distress had the same frequency, but the failures of trial were significantly higher in the oxytocin group than in the PGE&lt;sub&gt;2&lt;\/sub&gt; group (20.7 vs. 6%, p &lt; 0.01). Twenty-four percent of women needed a second PGE&lt;sub&gt;2&lt;\/sub&gt; dose, and almost half of the women in the PGE&lt;sub&gt;2&lt;\/sub&gt; group experienced \u2018spontaneous\u2019 labor. More neonates in the oxytocin group had 5-min Apgar scores &lt; 7 (p &lt; 0.05). Intracervical PGE&lt;sub&gt;2&lt;\/sub&gt; gel application is superior to intravenous oxytocin in terms of shortening the induction-delivery interval and increasing the frequency of successful vaginal delivery. In addition, it is safe for mother and fetus.<\/jats:p>","DOI":"10.1159\/000292734","type":"journal-article","created":{"date-parts":[[2010,3,2]],"date-time":"2010-03-02T02:53:55Z","timestamp":1267498435000},"page":"92-96","source":"Crossref","is-referenced-by-count":11,"title":["Labor Characteristics of Uncomplicated Prolonged Pregnancies after Induction with Intracervical Prostaglandin E\n                    <sub>2<\/sub>\n                    Gel versus Intravenous Oxytocin"],"prefix":"10.1159","author":[{"given":"Ioannis","family":"Papageorgiou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Tsionou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios","family":"Minaretzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Michalas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionysios","family":"Aravantinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,3,2]]},"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000292734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:13:09Z","timestamp":1777615989000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000292734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000292734","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,2]]}}}