{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:51:25Z","timestamp":1777891885602,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,3,2]],"date-time":"2010-03-02T00:00:00Z","timestamp":1267488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,3,2]],"date-time":"2010-03-02T00:00:00Z","timestamp":1267488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"abstract":"<jats:p>Few in vivo studies have attempted to characterize the effects of cocaine on the maternal and fetal pituitary-adrenal axis during pregnancy. We, therefore, administered cocaine (2 mg\u00b7kg-1) intravenously to 6 fetal sheep at 127\u2013138 days of gestation. There was a transient reduction in fetal arterial pO&lt;sub&gt;2&lt;\/sub&gt; with a concomitant increase in pCO&lt;sub&gt;2&lt;\/sub&gt; and a prolonged fall in pH (p &lt; 0.05) following cocaine injection. No changes were seen in maternal pO&lt;sub&gt;2&lt;\/sub&gt; pCO&lt;sub&gt;2&lt;\/sub&gt; or pH. Maternal plasma adrenocorticotropin, cortisol and lactate were not affected by fetal administration of cocaine. Although there was a tendency for fetal plasma adrenocorticotropin, cortisol and lactate to rise after administering cocaine, the increases were not statistically significant. Previous studies have shown that cocaine administration to the ewe at a similar stage of pregnancy results in increased fetal plasma adrenocorticotropin concentrations. The results of the present study indicate that cocaine administration to the fetus compromises fetal gas exchange and acid base balance, but the effects on the fetal pituitary-adrenal axis are less pronounced than after maternal administration of cocaine.<\/jats:p>","DOI":"10.1159\/000293030","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T03:01:26Z","timestamp":1267585286000},"page":"196-199","source":"Crossref","is-referenced-by-count":1,"title":["Lack of Effect of Fetal Administration of Cocaine on Maternal and Fetal Plasma Adrenocorticotropin, Cortisol and Lactate Concentrations at 127\u2013138 Days Gestational Age"],"prefix":"10.1159","author":[{"given":"J.R.","family":"Owiny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.T.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sadowsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Massmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.Y.","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.W.","family":"Nathanielsz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,3,2]]},"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000293030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:14:00Z","timestamp":1777616040000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000293030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000293030","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,2]]}}}