{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:56:31Z","timestamp":1777892191194,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,3,15]],"date-time":"2010-03-15T00:00:00Z","timestamp":1268611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,3,15]],"date-time":"2010-03-15T00:00:00Z","timestamp":1268611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"abstract":"<jats:p>The level of human fibronectin receptor (FNR) in plasma was measured by enzyme-linked immunosorbent assay in samples from normal pregnant women in the 1 st trimester (n = 5), 2nd trimester (n = 7), 3rd trimester (n = 23), normal postpartum women day 1 (n = 4), day 2 (n = 5), day 3 (n = 8), nonpregnant women (n = 18), 20 preeclamptic patients in the 3rd trimester, and 8 patients with abruptio placentae in the 3rd trimester. In normal pregnancy, the mean value of FNR was 1.4 \u00b1 0.4 \u00b5g\/ml in the 1st, 1.4 \u00b1 0.2 \u00b5g\/ml in the 2nd, and 1.9 \u00b1 0.3 \u00b5g\/ml (p &lt; 0.05) in the 3rd trimester. FNR values increased with pregnancy. During the puerperium, its level decreased with time, being 1.4 \u00b1 0.5 \u00b5g\/ml (p &lt; 0.01) on day 1, 1.0 \u00b1 0.3 \u00b5g\/ml on day 2, and 0.8 \u00b1 0.2 \u00b5g\/ml on day 3. The level in preeclamptic patients was 2.0 \u00b1 0.4 \u00b5g\/ml, and that in abruptio placentae was 2.7 \u00b1 0.4 \u00b5g\/ml. There were significant differences between the levels in abruptio placentae versus pre-eclampsia (p &lt; 0.05) and 3rd-trimester normal pregnant women (p &lt; 0.01). In the immunohistochemical study, the surface of normal decidual cells stained weakly for FNR, and the decidual cell membranes of the cases of pre-eclampsia stained moderately or strongly. Decidual cells and their extracellular matrix close to hematomas of abruptio placentae stained very strongly for FNR. FNR was also detected on the surface of chorionic villi, and the intensity of its staining in this region did not change in preeclampsia or abruptio placentae. These findings suggest that the plasma FNR value during pregnancy reflects its production in the placenta, and that a marked increase of FNR may predict the onset of preeclampsia or abruptio placentae.<\/jats:p>","DOI":"10.1159\/000294869","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T04:07:18Z","timestamp":1268712438000},"page":"147-152","source":"Crossref","is-referenced-by-count":3,"title":["Plasma Fibronectin Receptor Levels during Pregnancy Complicated by Preeclampsia and Abruptio Placentae"],"prefix":"10.1159","author":[{"given":"Naohiro","family":"Kanayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Terao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,3,15]]},"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000294869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:20:09Z","timestamp":1777616409000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000294869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,15]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000294869","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,15]]}}}