{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:34:16Z","timestamp":1789450456289,"version":"build-2803163510"},"reference-count":11,"publisher":"S. Karger AG","issue":"1-3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; \u03b1-Synuclein (AS) is an abundant neuronal protein predominantly localized in presynaptic terminals in the central nervous system. AS aggregation is a molecular hallmark of several neurodegenerative diseases, including Parkinson\u2019s disease, and is thought to play a significant role in the etiology of the disease. Recent experimental evidence indicates that AS exists in two forms, a membrane-bound form and a disordered cytosolic form. Much effort is dedicated to prevent and dissolve AS aggregates, specifically AS oligomers and protofibrils, which are thought to be the more toxic form of aggregates. &lt;i&gt;Methods:&lt;\/i&gt; The effect of filamentous phages on AS aggregation in SH-SY5Y cells overexpressing wild-type AS was quantified in ELISA designed to detect and quantify AS oligomers. &lt;i&gt;Results:&lt;\/i&gt; We found reduced levels of AS oligomers in the membrane fraction in cells treated with filamentous phages compared to nontreated cells. &lt;i&gt;Conclusion:&lt;\/i&gt; The reduction in AS oligomers from the plasma membrane in treated cells may suggest further therapeutic application.<\/jats:p>","DOI":"10.1159\/000295664","type":"journal-article","created":{"date-parts":[[2010,3,11]],"date-time":"2010-03-11T09:26:54Z","timestamp":1268299614000},"page":"203-205","source":"Crossref","is-referenced-by-count":9,"title":["Filamentous Phages Reduce \u03b1-Synuclein Oligomerization in the Membrane Fraction of SH-SY5Y Cells"],"prefix":"10.1159","volume":"7","author":[{"given":"Hemi","family":"Dimant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beka","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,3,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.276.5321.2045"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.10795"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0298-106"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2F3311"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.287.5456.1265"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2F35006074"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-2836%2802%2900735-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M107045200"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2009.04.048"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.03-1449com"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuron.2005.05.010"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/295664","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/295664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:15:37Z","timestamp":1745439337000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000295664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":11,"journal-issue":{"issue":"1-3","published-online":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000295664","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}