{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:21:15Z","timestamp":1790187675480,"version":"4.1.0"},"reference-count":31,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; Ovarian adrenal rest tumors (OARTs) are rare in contrast to testicular adrenal rest tumors. We report a case of OART in a patient with congenital adrenal hyperplasia who developed Nelson\u2019s syndrome after bilateral adrenalectomy. &lt;i&gt;Methods:&lt;\/i&gt; We describe the clinical, imaging, and laboratory findings of the patient and review the relevant literature regarding OART and the possible interaction between ACTH and brown adipose tissue. &lt;i&gt;Results:&lt;\/i&gt; An 18-year-old female with congenital adrenal hyperplasia, who had undergone bilateral adrenalectomy at the age of 10 years, presented with severe hyperpigmentation and hirsutism. Rectal ultrasonography showed a mass in the right ovary. &lt;sup&gt;18&lt;\/sup&gt;F-fluorodeoxyglucose PET\/CT revealed intense uptake both in this mass and in brown adipose tissue located in typical supradiaphragmatic sites. Laparoscopic removal of the ovarian mass confirmed the diagnosis of OART. A systematic review revealed 9 documented cases of OART. As in our case, all presented with elevated ACTH levels. &lt;i&gt;Conclusions:&lt;\/i&gt; Common to all documented cases of OART are sustained high ACTH levels that activate the adrenal anlagen tissue in the ovaries.<\/jats:p>","DOI":"10.1159\/000295722","type":"journal-article","created":{"date-parts":[[2010,8,9]],"date-time":"2010-08-09T06:56:32Z","timestamp":1281336992000},"page":"223-228","source":"Crossref","is-referenced-by-count":54,"title":["Ovarian Adrenal Rest Tumor in a Congenital Adrenal Hyperplasia Patient with Adrenocorticotropin Hypersecretion following 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