{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:39:59Z","timestamp":1745469599003,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Aim:&lt;\/i&gt; It was to establish whether brain natriuretic peptide (BNP) might predict cardiac dysfunction in children with chronic kidney disease (CKD). &lt;i&gt;Methods:&lt;\/i&gt; The relation between BNP, echocardiography and risk factors (hypertension, anemia, lipids, CRP, hyperparathyroidism) was investigated in 46 children (10 pre-dialysis patients, 14 on dialysis, 11 children with kidney transplants, and 11 healthy controls). Data on BNP were transformed into common logarithms (log&lt;sub&gt;10&lt;\/sub&gt; BNP, log BNP). &lt;i&gt;Results:&lt;\/i&gt; log BNP was significantly higher in dialysis patients when compared to controls (2.09 \u00b1 0.78 vs. 1.43 \u00b1 0.34 pg\/ml, p = 0.012) and patients in the pre-dialysis stage (2.09 \u00b1 0.78 vs. 1.52 \u00b1 0.42 pg\/ml, p = 0.039). log BNP in transplanted children was not significantly different from healthy children (2.09 \u00b1 0.78 vs. 1.71 \u00b1 0.46 pg\/ml, p = 0.19). Abnormal heart geometry (concentric and eccentric hypertrophy, concentric remodeling) was found in 19 patients (54.28%). A significant correlation was observed between log BNP and ventricular hypertrophy (r = 0.515, p = 0.001). Compared to controls higher log BNP was seen in children with eccentric hypertrophy than in children with concentric hypertrophy (2.178 \u00b1 0.956 vs. 1.496 \u00b1 0.395 pg\/ml, p = 0.05, or 1.982 \u00b1 0.618 vs. 1.496 \u00b1 0.395, p = 0.04). &lt;i&gt;Conclusions:&lt;\/i&gt; BNP might predict an abnormal geometry in children with CKD.<\/jats:p>","DOI":"10.1159\/000295895","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T08:07:18Z","timestamp":1268726838000},"page":"87-93","source":"Crossref","is-referenced-by-count":7,"title":["Elevated Brain Natriuretic Peptide Is Associated with Abnormal Heart Geometry in Children with Chronic Kidney Disease"],"prefix":"10.1159","volume":"33","author":[{"given":"J.","family":"Hedvig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u013d.","family":"Podrack\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Poto\u010dekov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,3,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.1998.v32.pm9820470"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2002.00472.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004670000303"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000019641.41496.1E"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00814.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2899%2980200-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjhyper.2004.08.032"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199005313222203"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005030276"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.00525.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI108079"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4065%2F76.11.1111"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1989.192"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2Fhy1001.096358"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/295895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/295895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:18:30Z","timestamp":1745439510000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000295895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000295895","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"type":"print","value":"1420-4096"},{"type":"electronic","value":"1423-0143"}],"subject":[],"published":{"date-parts":[[2010]]}}}