{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:59:03Z","timestamp":1792421943731,"version":"4.5.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Introduction:&lt;\/i&gt; Wnt-1 is capable of inducing metanephric mesenchyme to undergo tubulogenesis. A relationship between the degree of cystogenesis and reduced E-cadherin (E-cad) expression was described. Syndecan-1 (Sdc-1) has a critical role in kidney development. &lt;i&gt;Materials and Methods:&lt;\/i&gt; Ten multicystic dysplastic kidneys (MCDKs) were stained with hematoxylin and eosin and immunohistochemistry was performed using Wnt-1, E-cad and Sdc-1 antibodies. Eight unaffected kidneys were used as controls. &lt;i&gt;Results:&lt;\/i&gt; Strong Wnt-1 immunostaining occurred inside cystic\/tubular epithelial cells and in blastematous foci. An immunoreaction was observed in glomerular epithelial cells. In controls, just weak cytoplasmic Wnt-1 positivity was seen in tubular epithelial cells. E-cad reaction was negative in MCDKs while strong immunostaining was common in tubular cells of controls. A strong Sdc-1 immunoreaction depicted cystic, tubular and glomerular epithelial cells in MCDKs while Sdc-1 expression documented weak positivity in tubular epithelium alone. &lt;i&gt;Conclusions:&lt;\/i&gt; Our data are in accordance with an involvement of Wnt-1 in normal nephrogenesis and with its role in altered epithelial differentiation of metanephric mesenchyme in MCDKs. Wnt-1 signal may function to suppress E-cad expression, a predisposing event for cystogenesis. High expression of Sdc-1 in tubular\/cystic epithelial cells of MCDKs might alter the normal transition of stages of the developmental process and modify the anion charge of the glomerular barrier.<\/jats:p>","DOI":"10.1159\/000296285","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T07:09:54Z","timestamp":1280128194000},"page":"106-111","source":"Crossref","is-referenced-by-count":3,"title":["Molecular Events Involved in the Morphogenesis of Multicystic Dysplastic Kidney"],"prefix":"10.1159","volume":"85","author":[{"given":"Salvatore","family":"Arena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Fazzari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Scuderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Implatini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Villari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santo","family":"Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Arena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Di Benedetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.24.1.57"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2861%2980265-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F17.suppl_9.37"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.149.7.1433"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1006%2Fdbio.1994.1360"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.93.17.9021"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.149.1.111"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00362.2007"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ydbio.2004.04.029"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1242%2Fdev.01089"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0012-1606%2892%2990130-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.00451.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000190325"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2893%2990515-R"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004280100420"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1996.18"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.149.7.1433"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.physiol.62.1.595"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F14.9.2119"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5002514"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/296285","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/296285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:22:01Z","timestamp":1745439721000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000296285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,7,1]]},"published-print":{"date-parts":[[2010,8,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000296285","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}