{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:25:22Z","timestamp":1773307522761,"version":"3.50.1"},"reference-count":44,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; In this study we tested the hypothesis that H&lt;sub&gt;2&lt;\/sub&gt;S regulates collagen deposition, matrix metalloproteinases (MMP) and inflammatory molecules during hyperhomocysteinemia (HHcy) resulting in attenuation of glomerulosclerosis and improved renal function. &lt;i&gt;Materials and Methods:&lt;\/i&gt; A genetic model of HHcy, cystathionine \u03b2-synthase heterozygous (CBS+\/\u2013) and wild-type (WT) 2-kidney (2K) mice were used in this study and supplemented with or without NaHS (30 \u00b5mol\/l, H&lt;sub&gt;2&lt;\/sub&gt;S donor) in drinking water for 8 weeks. To expedite the renal damage associated with HHcy, uninephrectomized (1K) mice of similar groups were also used. &lt;i&gt;Results:&lt;\/i&gt; Results demonstrated that NAD(P)H oxidase (p47&lt;sup&gt;phox&lt;\/sup&gt;subunit) and blood pressure were upregulated in WT 1K, CBS+\/\u2013 2K and CBS+\/\u2013 1K mice with downregulation of H&lt;sub&gt;2&lt;\/sub&gt;S production and reduced glomerular filtration rate. These changes were normalized with H&lt;sub&gt;2&lt;\/sub&gt;S supplementation. Both pro- and active MMP-2 and -9 and collagen protein expressions and glomerular depositions were also upregulated in WT 1K, CBS+\/\u2013 2K and CBS+\/\u2013 1K mice. Increased expressions of inflammatory molecules, intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1, as well as increased macrophage infiltration, were detected in WT 1K, CBS+\/\u2013 2K and CBS+\/\u2013 1K mice. These changes were ameliorated with H&lt;sub&gt;2&lt;\/sub&gt;S supplementation. &lt;i&gt;Conclusion:&lt;\/i&gt; Together, these results suggest that increased oxidative stress and decreased H&lt;sub&gt;2&lt;\/sub&gt;S in HHcy causes matrix remodeling and inflammation resulting in glomerulosclerosis and reduced renal function.<\/jats:p>","DOI":"10.1159\/000296717","type":"journal-article","created":{"date-parts":[[2010,4,16]],"date-time":"2010-04-16T06:43:02Z","timestamp":1271400182000},"page":"442-455","source":"Crossref","is-referenced-by-count":65,"title":["Hydrogen Sulfide Regulates Homocysteine-Mediated Glomerulosclerosis"],"prefix":"10.1159","volume":"31","author":[{"given":"Utpal","family":"Sen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charu","family":"Munjal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natia","family":"Qipshidze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwasegun","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riyad","family":"Gargoum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh 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