{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:27:08Z","timestamp":1762176428112,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background and Aims:&lt;\/i&gt; The adenoma-carcinoma sequence is the model for colorectal carcinoma (CRC) developing through high-grade dysplasia (HGD) to CRC. The aim was to assess prevalence and location of adenomas found during colonoscopy and risk factors for HGD. &lt;i&gt;Material and Methods:&lt;\/i&gt; A population-based study using all colonoscopies and polyp specimens registered between 2000 and 2004 in Iceland. Multiple logistic regression analysis was used to assess independent risk factors for HGD. &lt;i&gt;Results:&lt;\/i&gt; A total of 3,315 adenomas were removed from 2,385 patients. Only 14.0% were &gt;1 cm in size. HGD was found in 135 (4.1%) of the adenomas and tubulovillous\/villous histology in 15.0%. The prevalence of adenomas in the 50- to 69-year age group was 15.5%, and 21.5% in the \u226770-year group. 60.9% of them were located distal to the splenic flexure. Independent risk factors for HGD were in the order of importance: size; multiplicity; tubulovillous\/villous histology; location in rectum, and age. The prevalence of HGD in the group with an adenoma size of 0.6\u20131.0 cm was 4.1% and in the 40- to 69-year age group it was 3.7%. &lt;i&gt;Conclusion:&lt;\/i&gt; The study suggests a potential 15% yield per colonoscopy of adenomas in 50- to 69-year-olds. There is an appreciable risk of HGD in diminutive polyps and in middle age.<\/jats:p>","DOI":"10.1159\/000297161","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T07:14:21Z","timestamp":1277363661000},"page":"252-257","source":"Crossref","is-referenced-by-count":7,"title":["Colonic Adenomas Found via Colonoscopy: Yield and Risk Factors for High-Grade Dysplasia"],"prefix":"10.1159","volume":"82","author":[{"given":"Sjofn","family":"Kristjansdottir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon G.","family":"Jonasson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Cariglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjarni","family":"Thjodleifsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.23.10.835"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28197905%2943%3A5%3C1847%3A%3AAID-CNCR2820430538%3E3.0.CO%3B2-L"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02630528"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.1996.v111.pm8898630"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5107%2800%2970444-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200007203430301"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2008.02.002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199203053261002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1148%2Fradiol.2373050176"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa0800996"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-200202000-00013"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-197912000-00001"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/297161","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/297161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:31:21Z","timestamp":1745440281000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000297161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,8,1]]},"published-print":{"date-parts":[[2010,8,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000297161","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2010]]}}}