{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:46:13Z","timestamp":1791902773307,"version":"4.3.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Objectives:<\/i> The \u2013765G>C variation (rs20417 SNP) in the promoter of cyclooxygenase-2 (COX-2) gene has been demonstrated to lower COX-2 enzyme activity in the vasculature, thus affecting atherosclerotic plaque growth and stability. Therefore, this genetic variant may be a candidate influencing the residual risk. <i>Methods:<\/i> In 285 coronary patients the incidence of major adverse cardiovascular events (MACEs), defined as a composite of cardiovascular deaths, non-fatal myocardial infarction and stroke, unstable angina and revascularization procedures, was monitored for a median of 7.8 years. The genotypes were obtained in 231 patients (81%) by PCR amplification and FAU I digestion. <i>Results:<\/i> 89 MACEs (38.5%) were recorded during the follow-up in genotyped patients. Their incidence was not different in patients with GC or CC when compared with those with GG genotype (46.2 vs. 35.5% respectively; p = 0.14). Kaplan-Meyer analysis did not demonstrate any influence of <i>COX-2<\/i> genotypes on the event-free survival time (log-rank p = 0.55). After controlling for confounders, the \u2013765G>C carrier status was not associated with significant variation in the risk of MACE or its individual components. <i>Conclusions:<\/i> These results suggest that the functional G\u2013765C variant in the <i>COX-2<\/i> gene is not a significant predictor of the recurrence of ischemic events in coronary patients.<\/jats:p>","DOI":"10.1159\/000298880","type":"journal-article","created":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T11:27:05Z","timestamp":1268998025000},"page":"236-242","source":"Crossref","is-referenced-by-count":6,"title":["Functional rs20417 SNP (\u2013765G>C) of Cyclooxygenase-2 Gene Does Not Predict the Risk of Recurrence of Ischemic Events in Coronary Patients: Results of a 7-Year Prospective Study"],"prefix":"10.1159","volume":"115","author":[{"given":"Anna","family":"Montali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Barill\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Tanzilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Vestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Fraioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Gaudio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mezzetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cipollone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Arca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2967394-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa050461"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2007.06.049"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc0902.104353"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2005.08.035"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000121735.52471.AC"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc3401.093152"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00005344-200605001-00006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000030340.80207.C5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.0000035402.68085.A0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cca.2005.12.019"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.291.18.2221"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehm161"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2897%2905381-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1538-7836.2006.02054.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.clpt.6100221"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2007.02.010"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mbc.0000214706.88621.da"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mbc.0000161563.36270.a2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1155%2F2008%2F289453"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161%2FATVBAHA.107.154823"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/298880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/298880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:47:58Z","timestamp":1745437678000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000298880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,4,1]]},"published-print":{"date-parts":[[2010,4,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000298880","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}