{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:09:25Z","timestamp":1761743365333,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gyn\u00e4kol Geburtshilfliche Rundsch"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Der Morbus Paget ist eine seltene Erkrankung der Vulva, welche weniger als 1% aller Neoplasien der Vulva ausmacht. Die \u00fcbliche Therapie besteht in der lokalen chirurgischen Entfernung. W\u00e4hrend die invasive Form des Morbus Paget selten ist, stellen die h\u00e4ufigen Lokalzrezidive, welche nicht mehr chirurgisch behandelt werden k\u00f6nnen, ein bedeutendes klinisches Problem dar. Bei einer 71-j\u00e4hrigen Patientin wurde ein solches Rezidiv erfolgreich mit Imiquimodsalbe behandelt. Die Juckreizsymptome bildeten sich nach kurzer Zeit zur\u00fcck. Nach 4 Wochen waren die kolposkopisch sichtbaren Hauterscheinungen r\u00fcckl\u00e4ufig. Innerhalb von 8 Wochen kam es zu einer kompletten klinischen Remission. Die Lokalbehandlung mit Imiquimod ist demnach nicht nur bei der vulv\u00e4ren intraepithelialen Neoplasie erfolgversprechend, sondern stellt auch bei ausgew\u00e4hlten Patientinnen mit rezidivierendem Morbus Paget der Vulva eine konservative Behandlungsalternative dar.<\/jats:p>","DOI":"10.1159\/000301110","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T07:28:17Z","timestamp":1274340497000},"page":"326-330","source":"Crossref","is-referenced-by-count":14,"title":["Morbus Paget der Vulva: Remission durch Lokalbehandlung mit Imiquimod \u2013 Fallbericht und Literatur\u00fcbersicht"],"prefix":"10.1159","volume":"49","author":[{"given":"Serena","family":"Bertozzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambrogio P.","family":"Londero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arrigo","family":"Fruscalzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Marchesoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.J.","family":"Lell\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2559.2006.02405.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F01.dad.0000194052.65695.f1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2899%2970143-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2006.09.017"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2002.125700"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fmodpathol.3800243"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2006-924608"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2007.12.014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000093854"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fmodpathol.3800437"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2005.06865.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10227-005-0023-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa072685"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2002.126584"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1067%2FS0190-9622%2803%2902107-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2230.28.s1.12.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F01.smj.0000209223.68763.b1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2FLGT.0b013e31815a58a5"}],"container-title":["Gyn\u00e4kologisch-geburtshilfliche Rundschau"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/301110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/301110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:12:00Z","timestamp":1745439120000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000301110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000301110","archive":["Portico"],"relation":{},"ISSN":["1018-8843","1423-0011"],"issn-type":[{"type":"print","value":"1018-8843"},{"type":"electronic","value":"1423-0011"}],"subject":[],"published":{"date-parts":[[2009]]}}}