{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:44:48Z","timestamp":1767339888431,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background and Study Aim:&lt;\/i&gt; Because of the small biopsy specimens in the Waldeyer\u2019s ring (WR) the differential diagnosis between Epstein-Barr virus (EBV)-associated lymphoproliferative disorder (LPD) and malignant lymphoma is occasionally difficult. We report here clinicopathological, immunohistochemical and genotypic findings of 9 cases of EBV-associated LPDs in WR. &lt;i&gt;Patients and Methods:&lt;\/i&gt; Using formalin-fixed paraffin-embedded sections, histological analyses, immunohistochemistry, in situ hybridization and polymerase chain reaction were performed. &lt;i&gt;Results:&lt;\/i&gt; Clinically, all 9 cases showed more than one atypical clinical finding of infectious mononucleosis including absence of systemic symptoms, absence of atypical lymphocytosis and age over 30 years. Histologically, 3 types were delineated: (1) Hodgkin lymphoma-like (n = 1), (2) T cell\/histiocyte-rich large B cell lymphoma-like (n = 4), and (3) marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT)-like (n = 4). The in situ hybridization study demonstrated EBV-encoded small RNA (EBER)+ cells in all 9 lesions. The immunohistochemical and flow cytometry study demonstrated the reactive nature of the B cells in all 9 lesions. However, 3 of our 7 cases examined demonstrated immunoglobulin heavy chain gene rearrangement on PCR study. There was no development of B cell lymphoma in any of the 3 lesions demonstrating IgH rearrangement. &lt;i&gt;Conclusion:&lt;\/i&gt; EBV-associated LPDs of the WR showed marked histological diversity. Among these, a MALT-like pattern was frequently seen. Marginal zone B cell lymphoma frequently affects WR. We emphasized that EBV-associated LPD should be added to the differential diagnosis of primary tonsillar MALT-type lymphoma.<\/jats:p>","DOI":"10.1159\/000301154","type":"journal-article","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T08:56:16Z","timestamp":1278579376000},"page":"218-224","source":"Crossref","is-referenced-by-count":9,"title":["Epstein-Barr Virus-Related Atypical Lymphoproliferative Disorders in Waldeyer\u2019s Ring: A Clinicopathological Study of 9 Cases"],"prefix":"10.1159","volume":"77","author":[{"given":"Masaru","family":"Kojima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazuki","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Tamaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhide","family":"Masawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,7,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0046-8177%2874%2980006-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-198702000-00006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199107000-00003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.prp.2007.05.002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs12253-008-9033-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2400998"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28197105%2927%3A5%3C1029%3A%3AAID-CNCR2820270505%3E3.0.CO%3B2-W"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199512000-00010"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109%2F10428190109057964"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fpath.1711670302"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2559.2002.01291.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177%2F1066896907307039"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2559.1987.tb02654.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199007000-00007"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2559.2008.02965.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.1890450114"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2895%2990960-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038%2Fmodpathol.3800369"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1827.2009.02466.x"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/301154","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/301154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:12:34Z","timestamp":1745439154000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000301154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,7,1]]},"published-print":{"date-parts":[[2010,7,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000301154","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"type":"print","value":"1015-2008"},{"type":"electronic","value":"1423-0291"}],"subject":[],"published":{"date-parts":[[2010]]}}}