{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:13:22Z","timestamp":1777893202505,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T00:00:00Z","timestamp":1268956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T00:00:00Z","timestamp":1268956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"abstract":"<jats:p>(1) The antiandrogenic steroid cyproterone acetate exerted a strongly negative nitrogen balance in 8 young male volunteers, the degree of which correlated with the dose administered. In a male patient of 77 years with cancer of the prostate, this catabolic effect proved to be much weaker. In 8 female patients with hirsutism, administration of cyproterone acetate resulted only then in a negative nitrogen balance when the food was deficient in calories and protein. Continuous treatment with cyproterone acetate in female patients is not feasible because of strongly progestational side-effects. These side effects can be avoided by combining cyproterone acetate with ethinyl estradiol as an \u2018inverted sequential scheme\u2019, according to Hammerstein and Cupceancy [2]. In most female patients with hirsutism, good or satisfactory results can be obtained by a continuous cyproterone acetate therapy or by the combination treatment of Hammerstein and CUPCEANCY [2].<\/jats:p>","DOI":"10.1159\/000301868","type":"journal-article","created":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T07:27:05Z","timestamp":1268983625000},"page":"282-289","source":"Crossref","is-referenced-by-count":7,"title":["Clinical-Pharmacological Investigation of Cyproterone Acetate"],"prefix":"10.1159","author":[{"given":"R.G.A.","family":"van Wayjen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"van den Ende","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,3,19]]},"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/301868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000301868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:51:02Z","timestamp":1777618262000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000301868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000301868","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,19]]}}}