{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:36:54Z","timestamp":1792517814205,"version":"4.5.0"},"reference-count":30,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; To evaluate the efficacy and safety of &lt;i&gt;Serenoa repens&lt;\/i&gt; + selenium and lycopene (Profluss\u00ae) versus &lt;i&gt;S. repens&lt;\/i&gt; alone for the treatment of category IIIa chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS). &lt;i&gt;Patients and Methods:&lt;\/i&gt; 102 patients with IIIa CP\/CPPS were enrolled and randomized into two groups each to receive Profluss or &lt;i&gt;S. repens&lt;\/i&gt; alone for 8 weeks. Evaluation was based on results of the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), IPSS, maximum peak flow rate (MPFR), and PSA measurements at baseline and at weeks 4, 8 and 8 after the end of treatment. The primary endpoint was a &gt;50% reduction in NIH-CPSI score. Secondary endpoints evaluated were MPFR, IPSS, PSA and white blood cell count. &lt;i&gt;Results:&lt;\/i&gt; No patients withdrew from the study. The mean NIH-CPSI score decreased significantly (p &lt; 0.001) in both groups; we observed a decrease in the total score from 27.45 to 13.27 in group 1 (\u201351.64%) and from 27.76 to 20.62 in group 2 (\u201326.06%). IPSS improved significantly (p &lt; 0.001) in both arms, but more in group 1. PSA and white blood cell count decreased significantly (p &lt; 0.007) only in group 1. The MPFR improved more in group 1 (p &lt; 0.005). &lt;i&gt;Conclusion:&lt;\/i&gt; Profluss is a triple therapy that is safe and well tolerated. It ameliorates symptoms associated with IIIa CP\/CPPS.<\/jats:p>","DOI":"10.1159\/000302716","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T07:59:57Z","timestamp":1274947197000},"page":"400-406","source":"Crossref","is-referenced-by-count":49,"title":["Treatment of Chronic Prostatitis\/Chronic Pelvic Pain Syndrome Category IIIA with &lt;i&gt;Serenoa repens&lt;\/i&gt; plus Selenium and Lycopene (Profluss\u00ae) versus &lt;i&gt;S. repens&lt;\/i&gt; Alone: An Italian Randomized Multicenter-Controlled 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