{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:59:03Z","timestamp":1775152743803,"version":"3.50.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Objective:<\/i> To evaluate the long-term efficacy and tolerability of nevirapine (NVP)-based regimens in the treatment of human immunodeficiency virus (HIV)-infected Chinese patients in routine clinical practice. <i>Methods:<\/i> From October 2002 to May 2004, 57 HIV-1-infected patients commenced antiretroviral therapy (ART), and were followed up to December 2008. These antiretroviral-na\u00efve patients, who originally received two nucleoside reverse transcriptase inhibitors and NVP, had HIV RNA levels, T lymphocyte subsets and safety parameters assessed over 6 years. <i>Results:<\/i> Of the 57 patients, 34 patients participated in the long-term follow-up. After 5\u20136 years, >60% of the patients had HIV RNA levels <50 copies\/\u00b5l, and the median increase in CD4 cell counts from baseline was 329 cells\/\u00b5l. \u03b3-Glutamyl transferase increased in 17 patients (29.8%); serum cholesterol and triglyceride levels were elevated in 15 patients (26.3%), and 25.0% (6\/24) of the patients developed lipodystrophy (mainly females). Grade 3\/4 adverse events occurred in 3 cases. <i>Conclusion:<\/i> ART with NVP-based regimens suppressed HIV viremia and produced continued CD4 cell increases in a majority of subjects for 6 years. Safety and tolerance were good with no unexpected long-term toxicity. Though based on a small group, this study demonstrates durable effects of ART in Chinese patients.<\/jats:p>","DOI":"10.1159\/000302762","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T07:11:08Z","timestamp":1269933068000},"page":"240-246","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of a 6-Year Highly Active Antiretroviral Therapy in Chinese HIV-1-Infected Patients"],"prefix":"10.1159","volume":"53","author":[{"given":"Hua-ying","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-huang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00002030-200310170-00011"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1089%2Fvim.2006.0047"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00002030-200209270-00002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00126334-200406010-00006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1086%2F500412"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F00002030-200401020-00005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00002030-200409240-00012"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1086%2F526524"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00002030-200311070-00009"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00002030-200202150-00007"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00002030-200309050-00009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2249.2000.01152.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2908468-2"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/302762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/302762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:10:00Z","timestamp":1745439000000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000302762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000302762","archive":["Portico"],"relation":{},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"value":"0300-5526","type":"print"},{"value":"1423-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}