{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:54:34Z","timestamp":1791078874397,"version":"4.1.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background: &lt;\/i&gt;The mechanisms of action of bexarotene are not well understood. &lt;i&gt;Methods:&lt;\/i&gt; A retrospective study on patients with cutaneous T-cell lymphoma (CTCL) treated with bexarotene was performed to see if bexarotene could act on the dominant T-cell clones. Thirty-five patients were included. Twenty-three were treated with bexarotene for more than 3 months (300 mg\/m&lt;sup&gt;2&lt;\/sup&gt;). In 7 patients, phototherapy was given with bexarotene. &lt;i&gt;Results: &lt;\/i&gt;Dominant T-cell clones were observed in 11 patients in peripheral blood and in 19 patients in skin. Our results demonstrate no significant evolution of T-cell clones either in skin or peripheral blood. Furthermore, the detection of T-cell clones in peripheral blood before starting bexarotene was significantly associated with the progression of the disease. UV therapy given with bexarotene significantly improved therapeutic response without any correlation with T-cell clones. &lt;i&gt;Conclusion:&lt;\/i&gt; This is the first study on the evolution of the T-cell clone in blood and skin in CTCL patients during bexarotene therapy.<\/jats:p>","DOI":"10.1159\/000305354","type":"journal-article","created":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T08:17:14Z","timestamp":1274084234000},"page":"370-375","source":"Crossref","is-referenced-by-count":17,"title":["Evolution of Clinical and Molecular Responses to Bexarotene Treatment in Cutaneous T-Cell Lymphoma"],"prefix":"10.1159","volume":"220","author":[{"given":"F.","family":"Ballanger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Khammari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Dr\u00e9no","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2002.01794.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.139.7.857"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2005.06539.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.141.3.315"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2004-09-3502"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2003.05.010"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0781.2007.00315.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2002.124607"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2009.09037.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.139.7.909"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jid.5701109"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2899%2970351-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.143.5.661"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/305354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/305354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:28:47Z","timestamp":1745436527000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000305354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,6,1]]},"published-print":{"date-parts":[[2010,6,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000305354","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}