{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:03:58Z","timestamp":1761059038912,"version":"3.40.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The flare-up effect of GnRH analogues may cause transient uterine bleeding in girls affected with idiopathic central precocious puberty (ICPP). &lt;i&gt;Aims:&lt;\/i&gt; To assess the incidence of endometrial bleeding and verify whether pretreatment with cyproterone acetate could counteract it. &lt;i&gt;Methods:&lt;\/i&gt; Fifty-four girls affected by ICPP were divided into 2 groups. The first group (30 girls) was treated with triptorelin (3.75 mg, i.m. injection) every 28 days. The second group (24 girls) was treated with cyproterone acetate and triptorelin: cyproterone acetate (50 mg\/m&lt;sup&gt;2&lt;\/sup&gt;) was administered every day for 8 weeks, and triptorelin (3.75 mg) was commenced 4 weeks after starting the cyproterone, then the intramuscular injection of triptorelin was repeated every 28 days. &lt;i&gt;Results:&lt;\/i&gt; Eight of 54 girls (15%) had mild withdrawal bleeding. There were no differences in incidence between groups 1 and 2. Girls with pubertal uterus at pelvic ultrasound had a higher incidence of uterine bleeding than girls with infantile uterus (25 vs. 7%), but this difference was not significant. &lt;i&gt;Conclusion:&lt;\/i&gt; Co-administration of cyproterone acetate and GnRH analogues does not significantly decrease the incidence of uterine bleeding.<\/jats:p>","DOI":"10.1159\/000308172","type":"journal-article","created":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T06:58:14Z","timestamp":1271228294000},"page":"386-389","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Treatment with Cyproterone Acetate on Uterine Bleeding at the Beginning of GnRH Analogue Therapy in Girls with Idiopathic Central Precocious Puberty"],"prefix":"10.1159","volume":"73","author":[{"given":"S.","family":"Seminara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Nanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Generoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Mirri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Leonardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Slabadzianiuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Vetrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Buongiorno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Losi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Galluzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fbeem.2002.0188"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.1.02056"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fedrv-7-1-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2Fj.1600-0412.1998.770314.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1530%2FEJE-08-0814"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198112243052602"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-58-6-966"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000180939"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2001-020243"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11596-006-0519-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2165%2F00003088-199834050-00005"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/308172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/308172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:03:07Z","timestamp":1745438587000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000308172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000308172","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2010]]}}}