{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:18:27Z","timestamp":1775845107120,"version":"3.50.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Background: Functional dyspepsia (FD) is a heterogeneous disease characterized by various upper abdominal symptoms. The major mechanism of FD symptoms includes impaired fundic accommodation, delayed gastric emptying, and visceral hypersensitivity. We developed a novel drinking-ultrasonography test to combine a drink test with ultrasonography to assess gastric motility and sensory function of FD patients. Method: Subjects were 60 successive FD patients according to the Rome III criteria. A drinking-ultrasonography test was performed after subjects had fasted. The subjects ingested 200 ml of water at 2-min intervals 4 times (total 800 ml) through a straw. The maximum cross section of the proximal stomach was visualized before water intake, after each water intake, and 5 and 10 min after the completion of drinking using extracorporeal ultrasonography. Abdominal symptoms were evaluated using the visual analog scale (VAS) a total of 5 times. The normal range of cross-sectional area and VAS were set using average \u00b1 standard deviations of 33 healthy volunteers. Cases outside the normal range were diagnosed with a motor or sensory disorder. Results: The drinking-ultrasonography test classified FD patients into four groups without adverse effect or trouble. The distribution of each group was 27% in the normal group, 15% in the impaired relaxation group, 10% in the delayed emptying group, and 48% in the visceral hypersensitivity group. There was no significant correlation between the pathophysiological classification and subtypes of FD defined by the Rome III criteria. Conclusion: We developed a novel drinking-ultrasonography test that was effective in classifying FD patients according to pathophysiological features.<\/jats:p>","DOI":"10.1159\/000308363","type":"journal-article","created":{"date-parts":[[2010,6,25]],"date-time":"2010-06-25T07:06:05Z","timestamp":1277449565000},"page":"162-166","source":"Crossref","is-referenced-by-count":13,"title":["Pathophysiological Classification of Functional Dyspepsia Using a Novel Drinking-Ultrasonography Test"],"prefix":"10.1159","volume":"82","author":[{"given":"Mototsugu","family":"Kato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urara","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsumi","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Hata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumiko","family":"Asaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahira","family":"Haneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouko","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Asaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,6,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2005.11.059"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2898%2970012-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F01.mcg.0000156109.97999.d1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2001.27180"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2982.2003.00431.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.52.11.1548"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1148%2Fradiol.2242011412"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2982.2007.00904.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.51.suppl_1.i59"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1746.2000.02251.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2002.05421.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2982.2004.00588.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.2003.025031"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2001.03683.x"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dig\/article-pdf\/82\/3\/162\/4034045\/000308363.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/82\/3\/162\/4034045\/000308363.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:05:01Z","timestamp":1745438701000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000308363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,6,1]]},"published-print":{"date-parts":[[2010,6,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000308363","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}