{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:17:35Z","timestamp":1791105455833,"version":"4.1.0"},"reference-count":38,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,7,30]],"date-time":"2010-07-30T00:00:00Z","timestamp":1280448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,7,30]],"date-time":"2010-07-30T00:00:00Z","timestamp":1280448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; This study tested the hypothesis that preterm infants who had a blood gas derangement on at least 2 of the first 3 postnatal days are at increased risk for more severe retinopathy of prematurity (ROP). &lt;i&gt;Method:&lt;\/i&gt; 1,042 infants born before 28 weeks\u2019 gestational age (GA) were included. An infant was considered to be exposed if his\/her blood gas measure was in the highest or lowest quartile for GA on at least 2 of the first 3 postnatal days. &lt;i&gt;Results:&lt;\/i&gt; Multivariable models adjusting for confounders indicate that exposure to a PCO&lt;sub&gt;2&lt;\/sub&gt; in the highest quartile predicts ROP (stage 3, 4 or 5: OR = 1.6, 95% CI = 1.1\u20132.3); zone 1: 2.0, 1.1\u20133.6; prethreshold\/threshold: 1.9, 1.2\u20133.0; plus disease: 1.8, 1.1\u20132.9). Estimates are similar for a low pH for zone 1 (2.1, 1.2\u20133.8), prethreshold\/threshold (1.8, 1.1\u20132.8), but did not quite achieve statistical significance for ROP stage 3, 4, or 5 (1.4, 0.9\u20132.0) and plus disease (1.5, 0.9\u20132.4). A PaO&lt;sub&gt;2&lt;\/sub&gt; in the highest quartile for GA on at least 2 of the first 3 postnatal days was associated with a doubling of the risk of ROP in zone 1 (2.5, 1.4\u20134.4) and of prethreshold\/threshold disease (2.1, 1.4\u20133.3), a 70% risk increase for plus disease (1.7, 1.04\u20132.8), while a 40% risk increase for ROP stage 3 or higher did not achieve statistical significance (1.4, 0.96\u20132.0). &lt;i&gt;Conclusion:&lt;\/i&gt; Infants exposed to high PCO&lt;sub&gt;2&lt;\/sub&gt;, low pH and high PaO&lt;sub&gt;2&lt;\/sub&gt; appear to be at increased risk of more severe ROP.<\/jats:p>","DOI":"10.1159\/000308454","type":"journal-article","created":{"date-parts":[[2010,7,30]],"date-time":"2010-07-30T07:14:47Z","timestamp":1280474087000},"page":"104-111","source":"Crossref","is-referenced-by-count":49,"title":["Blood Gases and Retinopathy of Prematurity: The ELGAN Study"],"prefix":"10.1159","volume":"99","author":[{"given":"Alisse K.","family":"Hauspurg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth N.","family":"Allred","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah K.","family":"Vanderveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis J.","family":"Bednarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Ehrenkranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Leviton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Dammann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fsiny.2001.0079"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.112.6.1415"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jp.7211067"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2009-0434"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00247-007-0605-z"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2006-1138"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2008-0594"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2008.04.013"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Faje%2Fkwn202"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2008-0862"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2008-1113"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-3782%2887%2990099-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2007.11.068"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080%2F00313020802035865"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1987.01060070042025"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.108.3.809"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.121.12.1684"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fsim.1524"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.112.5.1016"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS1091-8531%2897%2990008-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jp.7211878"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.earlhumdev.2008.12.010"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2006-1088"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1203%2FPDR.0b013e31818d1dbd"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1981.tb05725.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.2007.126201"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1080%2F02713689808951233"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00920938"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.85.9.1044"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.110.3.615"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2006-2200"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2009-2218"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.111.2.339"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaapos.2006.04.010"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2008.09.051"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1203%2FPDR.0b013e318199386a"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1097%2FMOP.0b013e3280895e12"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.2008.00933.x"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/308454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/308454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:05:40Z","timestamp":1745438740000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000308454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,30]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,2,1]]},"published-print":{"date-parts":[[2011,2,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000308454","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,30]]}}}