{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:03:41Z","timestamp":1777943021995,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"abstract":"<jats:p>Serotonin 5-HT&lt;sub&gt;1A&lt;\/sub&gt;-type and \u03b2-adrenergic receptors have similar molecular characteristics, which explains why certain substances like propranolol have affinities for both receptor types. Activation of 5-HT&lt;sub&gt;1A&lt;\/sub&gt; receptors leads to a decrease in intracellular cAMP levels whereas the opposite occurs for \u03b2-adrenergic receptors. Both 5-HT&lt;sub&gt;1A&lt;\/sub&gt; and \u03b2-adrenergic receptors exist in the rabbit ciliary processes. Topical application of the 5-HT&lt;sub&gt;1A&lt;\/sub&gt; agonist, 8-hydroxydipropylaminotetralin (8-OH-DPAT) reduces intraocular pressure (IOP). \u03b2-Antagonists are also known to reduce IOP It is postulated that substances which have an affinity for 5-HT&lt;sub&gt;1A&lt;\/sub&gt; and\/or \u03b2-adrenergic receptors and lead to a reduction in intracellular cAMP levels in the ciliary processes diminish IOP.<\/jats:p>","DOI":"10.1159\/000310730","type":"journal-article","created":{"date-parts":[[2010,4,6]],"date-time":"2010-04-06T22:56:00Z","timestamp":1270594560000},"page":"308-314","source":"Crossref","is-referenced-by-count":18,"title":["Do Beta-Adrenoceptors and Serotonin 5-HT\n                    <sub>1A<\/sub>\n                    Receptors Have Similar Functions in the Control of Intraocular Pressure in the Rabbit?"],"prefix":"10.1159","author":[{"given":"N.N.","family":"Osborne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Chidlow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,4,1]]},"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000310730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:13:27Z","timestamp":1777706007000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000310730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000310730","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,1]]}}}