{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:13:57Z","timestamp":1790140437523,"version":"4.0.1"},"reference-count":15,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Allergen sensitization through a disrupted skin barrier appears to play a prominent role in the development of atopic diseases, including allergic asthma. The role of the genetic background in immunological and physiological phenotypes induced by epicutaneous sensitization is undetermined. &lt;i&gt;Methods:&lt;\/i&gt; BALB\/c and C57BL\/6 mice were sensitized either epicutaneously by patch application of ovalbumin (OVA) or systemically by intraperitoneal injection of OVA with alum before exposure to aerosolized OVA. The concentrations of OVA-specific immunoglobulin in serum and cytokines in bronchoalveolar lavage fluid (BALF) were measured by enzyme-linked immunosorbent assay. The severity of airway inflammation was evaluated by cell counts in BALF, and bronchial responsiveness to methacholine was measured by the flexiVent system. &lt;i&gt;Results:&lt;\/i&gt; The production of OVA-specific IgG1 and IgE was greater in the epicutaneously sensitized BALB\/c than C57BL\/6 mice. In contrast, both eosinophilic airway inflammation and bronchial responsiveness to methacholine were more prominent in the C57BL\/6 than in the BALB\/c mice. The concentrations of interleukin-4 increased significantly in the BALF from C57BL\/6 mice only. No between-strain differences were observed after intraperitoneal sensitization. &lt;i&gt;Conclusions:&lt;\/i&gt; The C57BL\/6 mouse is a more appropriate model than the BALB\/c mouse to study the relationship between skin barrier dysfunction and the pathogenesis of allergic asthma.<\/jats:p>","DOI":"10.1159\/000312128","type":"journal-article","created":{"date-parts":[[2010,6,4]],"date-time":"2010-06-04T07:34:13Z","timestamp":1275636853000},"page":"67-74","source":"Crossref","is-referenced-by-count":29,"title":["Strain-Specific Phenotypes of Airway Inflammation and Bronchial Hyperresponsiveness Induced by Epicutaneous Allergen Sensitization in BALB\/c and C57BL\/6 Mice"],"prefix":"10.1159","volume":"152","author":[{"given":"Motohiro","family":"Kodama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Oguma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuko","family":"Kagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Tomomatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misa","family":"Wakaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Takihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Ohmori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyuto","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobufumi","family":"Kamiishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Fukunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Sayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Miyasho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitoshi","family":"Ishizaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,6,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2003.09.034"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2003.09.033"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fng1767"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2006.05.004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2007.04.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2006.04.046"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI1647"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2005.06.027"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.1998.00280.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2567.1999.00890.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0706942104"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI200214097"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1152%2Fjapplphysiol.00821.2003"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1063%2F1.1389334"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0625.2009.00899.x"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/312128","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/312128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:25:31Z","timestamp":1745436331000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000312128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":15,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2010,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000312128","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}